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https://www.tandfonline.com/doi/abs/10.1517/14712598.4.3.301
Apr 20, 2018 · Protein crystals have shown significant benefits in the delivery of biopharmaceuticals to achieve high concentration, low viscosity formulation and controlled release protein delivery.Author: Sujit K Basu, Chandrika P Govardhan, Chu W Jung, Alexey L Margolin
https://www.researchgate.net/publication/7733332_Protein_crystals_for_the_delivery_of_biopharmaceuticals
Protein crystals have shown significant benefits in the delivery of biopharmaceuticals to achieve high concentration, low viscosity formulation and controlled release protein delivery.
https://drug-dev.com/protein-crystals-reshaping-traditional-biotherapeutic-formulations/
Basu et al. Protein crystals for the delivery of biopharmaceuticals. Expert Opinion Biological Ther. 2004;4(3):301-317. Don Paul Kovarcik is the Technical Marketing Specialist at Ajinomoto Althea, Inc.
https://www.researchgate.net/publication/335716289_Stability_Formulation_and_Delivery_of_Biopharmaceuticals_in_Protein_Therapeutics_eds_T_Vaughan_J_Osbourn_B_Jallal_Wiley-VCH_2017_Part_IV_Vol_2_Chapter_14_pp_469-491
Protein therapeutics have emerged as a major class of biopharmaceuticals over the past several decades, a trend that has motivated the advancement of bioanalytical technologies for protein ...
https://www.sciencedirect.com/science/article/pii/S1818087616300411
4. Delivery systems employing protein crystals. In principle, controlled release from protein crystals can be achieved either with or without encapsulation of crystals into a polymeric system. Since some protein crystals already show delayed dissolution encapsulation can be avoided in some cases.Author: Sebastian Puhl, Lorenz Meinel, Oliver Germershaus
https://pubs.acs.org/doi/abs/10.1021/mp500809f
Jan 22, 2015 · A major barrier to successful oral delivery of peptide and protein molecules is their inherent instability in the lumen of the gastrointestinal tract. The aim of this study was to determine the stability of 17 disparate peptide drugs (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, [Arg8]-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin ...Author: J Wang, Yadav, AL Smart, S Tajiri, AW Basit
https://link.springer.com/content/pdf/10.1007%2Fs11095-005-6021-x.pdf
Aug 24, 2005 · The aim of the study is to solve a significant challenge of extending the half-life of therapeutic proteins using crystalline biopharmaceuticals and without redesigning the molecules. Crystals of recombinant human growth hormone were coated with a monomolecular layer of positively charged poly(arginine).Author: Chandrika Govardhan, Nazer Khalaf, Chu W. Jung, Ben Simeone, Amy Higbie, Susan Qu, Letha Chemmalil, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178630/
Sep 22, 2011 · Spiking experiments with protein contaminations, DNA and bacteriophage. Host cell proteins (HCPs), virus and DNA are critical impurities in the production of biopharmaceuticals. Therefore, spiking experiments using model protein impurities, genomic DNA and bacteriophage T7 as a virus model were carried out.Author: Yuguo Zang, Bernd Kammerer, Maike Eisenkolb, Katrin Lohr, Hans Kiefer
https://www.nature.com/articles/nrd4363
Aug 08, 2014 · Intracellular delivery of proteins and peptides is a new frontier in delivery research, which could dramatically augment the breadth of targets amenable to biopharmaceutical drug therapy…Author: Samir Mitragotri, Paul A. Burke, Robert Langer
http://www.thaiscience.info/journals/Article/TJPS/10576336.pdf
or bioprocessing is termed a biopharmaceutical [1, 2]. Biopharmaceutical drugs are large, complex protein molecules derived from living cells. Manufacturing of pharmaceutical proteins including antibodies has been reported on a large scale. The production systems available include mammalian cells, yeast, insect cellsFile Size: 143KB
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