We have collected information about Protein And Peptide Drug Delivery Oral Approaches for you. Follow the links to find out details on Protein And Peptide Drug Delivery Oral Approaches.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing and formulating a protein and peptide drug for delivery though GI tract requires a multitude of strategies. The dosage form must initially stabilize the drug making it easy to take orally 4. It must then protect the drug from the extreme acidity and action of pepsin in the stomach.
https://www.ncbi.nlm.nih.gov/pubmed/20046732
The main challenge is to improve the oral bioavailability from less than 1% to at least 30-50%. Consequently, efforts have intensified over the past few decades, where every oral dosage form used for the conventional small molecule drugs has been used to explore oral protein and peptide delivery.Author: Jessy Shaji, V Patole
https://www.researchgate.net/publication/40834786_Protein_and_Peptide_Drug_Delivery_Oral_Approaches
Recent work in the area of transdermal peptide and protein drug delivery is overviewed, including strategies such as prodrugs, chemical enhancement, iontophoresis, electroporation, and ultrasound ...
https://www.ijpsonline.com/articles/protein-and-peptide-drug-delivery-oral-approaches.html
Nov 10, 2006 · Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo aggregation, adsorption, and denaturation [12,13]. Consequently, the absolute oral bioavailability levels …Author: Jessy Shaji, V Patole
https://www.ijpsonline.com/articles/protein-and-peptide-drug-delivery-oral-approaches.pdf
Oral Delivery of Proteins and Peptides Till recent, injections remained the most common means for administering therapeutic proteins and peptides because of their poor oral bioavailability. However, oral route would be preferred to any other route because ofAuthor: Jessy Shaji, V Patole
https://www.sciencedirect.com/science/article/pii/B9780128179093000169
Most of these approaches mainly focus on the delivery of proteins and peptides by the oral route, as it is the most popular method of drug administration among patients because of its simplicity. However, other routes of administration such as the transdermal, nasal, and pulmonary route also have attractive features as alternative methods for therapeutic protein and peptide administration ( Brown, 2005 ).Author: Pran Kishore Deb, Omar Al-Attraqchi, Balakumar Chandrasekaran, Anant Paradkar, Rakesh K. Tekade
https://www.sciencedirect.com/science/article/pii/S1319016414000590
The two important approaches for formulation of protein and peptides by oral route include: use of absorption enhancers and enzymatic inhibitor. Being charged, large in size and hydrophilic, proteins and peptides are notoriously poor permeators (and thus exhibit poor oral bioavailability per se).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
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