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https://www.nejm.org/doi/full/10.1056/NEJMoa035140
Original Article from The New England Journal of Medicine — Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone CaproateAuthor: Paul J. Meis, Mark Klebanoff, Elizabeth Thom, Mitchell P. Dombrowski, Baha Sibai, Atef H. Moawad, Ca...
https://www.ncbi.nlm.nih.gov/pubmed/28947068
In general, progesterone is thought to maintain pregnancy through several closely linked mechanisms: (1) promotion of uterine quiescence, (2) inhibition of pro-inflammatory cells, and (3) immunosuppressive action. 17-Alpha hydroxyprogesterone caproate is currently the only medication approved to prevent recurrent preterm birth.Author: Tracy A. Manuck
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253874/
Prevention of Preterm Delivery with 17-Hydroxyprogesterone Caproate: Pharmacologic Considerations. ... Metabolites of 17-OHPC have been identified and differ from 17-hydroxyprogesterone or progesterone. The caproic acid moiety of 17-OHPC is not removed during metabolism, rather the steroid rings are primarily hydroxylated. ... including 17-OHPC ...Author: Maisa Feghali, Raman Venkataramanan, Steve Caritis
https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyprogesterone-caproate
Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate.It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid).Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug Administration (FDA) in 1956 …
https://www.sciencedirect.com/science/article/pii/S0146000514001013
Prevention of preterm delivery with 17-hydroxyprogesterone caproate: Pharmacologic considerations. ... including 17-OHPC, may avert preterm labor and delivery are less well determined. Most studies support a likely anti-inflammatory effect and a local increase in progesterone concentrations in gestational tissues, counteracting the functional ...Author: Maisa Feghali, Raman Venkataramanan, Steve Caritis
https://www.pharmacytimes.com/news/fda-advisory-board-votes-to-recommend-withdrawing-progesterone-therapy-for-preterm-birth
Oct 30, 2019 · Hydroxyprogesterone caproate injection is a progestin indicated to reduce the risk of preterm birth in women pregnant with a single baby who have a history of singleton spontaneous preterm birth. However, the advisory board voted unanimously that the most recent AMAG Pharmaceutical Meis study showed no benefit.
https://www.astho.org/Maternal-and-Child-Health/17P-Fact-Sheet/
17 Alpha-hydroxyprogesterone caproate (17P) Making the Case for 17P . Nearly 500,000 1babies are born preterm in the United States each year. Preterm birth (PTB), or birth less than 37 weeks gestation, puts infants at a higher risk of death and is the leading cause of longterm - …
https://www.acog.org/en/News/News%20Releases/2019/10/ACOG%20Statement%20on%2017p%20Hydroxyprogesterone%20Caproate
ACOG Statement on 17p Hydroxyprogesterone Caproate. Washington, DC—Christopher M. Zahn, ... placebo-controlled clinical trial evaluating 17-hydroxyprogesterone caproate ... recognizes that the PROLONG clinical trial evaluating 17p in patients with a history of a prior spontaneous singleton preterm delivery, demonstrated no statistical ...
Makena ® (hydroxyprogesterone caproate injection) prescribing information, AMAG Pharmaceuticals, 2018. 9. Northen AT, Norman GS, Anderson K, et al. Follow-up of children exposed in utero to 17 α-hydroxyprogesterone caproate compared with placebo. Obstet Gynecol. 2007;110(4):865-872.
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