Protamine Drug Delivery

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Protamine: Indications, Side Effects, Warnings - Drugs.com

    https://www.drugs.com/cdi/protamine.html
    There may be drug take-back programs in your area. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about protamine, please talk with your doctor, nurse, pharmacist, or other health care provider.Drug classes: Anticoagulant reversal agents, Heparin antagonists

Low molecular weight protamine-functionalized ...

    https://www.ncbi.nlm.nih.gov/pubmed/21937105
    Low molecular weight protamine-functionalized nanoparticles for drug delivery to the brain after intranasal administration. Xia H(1), Gao X, Gu G, Liu Z, Zeng N, Hu Q, Song Q, Yao L, …Author: Huimin Xia, Xiaoling Gao, Guangzhi Gu, Zhongyang Liu, Ni Zeng, Quanyin Hu, Qingxiang Song, Lei Yao, ...

Protamine Sulfate - an overview ScienceDirect Topics

    https://www.sciencedirect.com/topics/neuroscience/protamine-sulfate
    Protamine sulfate, which is administered by intravenous infusion, has an immediate onset and duration of action of about 2 hours. Dosing strategies to neutralize excessive anticoagulation induced by UFH are often based on the use of 1 mg of protamine to neutralize 80 to 100 USP U of heparin. 312 Because the action of protamine is shorter than that of heparin, follow-up coagulation tests should ...

Manufacturing of a Secretoneurin Drug Delivery System with ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102448/
    Within the last years, several drug delivery systems were described for the application of angiogenic compounds. Thereby, different types of nanoparticles were investigated, e.g. protamine/heparin nanoparticles for delivery of FGF growth factor [16, 17] or coated gold nanoparticles either to activate or inhibit angiogenesis in vitro ...Author: Bernhard Scheicher, Cornelia Lorenzer, Katrin Gegenbauer, Julia Partlic, Fritz Andreae, Alexander H....

Protamine–oligonucleotide-nanoparticles: Recent advances ...

    https://www.sciencedirect.com/science/article/pii/S0928098715001529
    Even without lipid coating hyaluronic acid is used to form nanoplexes with protamine in order to act as drug delivery system for peptides. Umerska et al. recently reported an oral delivery system for salmon calcitonin which showed prolonged release and successful protection against enzymatic digestion (Umerska et al., 2014). 4.2.Author: B. Scheicher, A.-L. Schachner-Nedherer, A. Zimmer

Protamine Insulin: Hagedorn's Pioneering Contribution to ...

    https://jamanetwork.com/journals/jama/fullarticle/391080
    Jan 20, 1984 · The epoch-making discovery of insulin by Banting and Best led to an appropriate euphoria among physicians treating diabetic patients. Death due to diabetic coma (diabetic ketoacidosis) was largely eliminated. Life expectancy in the child with newly discovered diabetes was …Author: Philip Felig

Protamine (Protamines): Uses, Dosage, Side Effects ...

    https://www.rxlist.com/protamine-drug.htm
    Feb 24, 2017 · Protamine Sulfate Injection, USP. DESCRIPTION. Protamine Sulfate Injection, USP is a sterile, non-pyrogenic, isotonic solution of protamine sulfate in Water for Injection. It acts as a heparin antagonist. It is also a weak anticoagulant.. Protamines are simple protein principles obtained from the sperm of salmon and certain other species of fish.

Manufacturing of a Secretoneurin Drug Delivery System with ...

    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164149
    Since therapeutic peptides and oligonucleotides are gathering interests as active pharmaceutical ingredients (APIs), nanoparticulate drug delivery systems are becoming of great importance. Thereby, the possibility to design drug delivery systems according to the therapeutic needs of APIs enhances clinical implementation. Over the last years, the focus of our group was laid on protamine ...Author: Bernhard Scheicher, Cornelia Lorenzer, Katrin Gegenbauer, Julia Partlic, Fritz Andreae, Alexander H....

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