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https://www.wiley.com/en-us/Prodrugs+and+Targeted+Delivery%3A+Towards+Better+ADME+Properties-p-9783527326037
Transporter-Targeted Prodrug Approach Drug Disposition in Ocular Delivery Effect of Physiochemical Factors on Drug Disposition in Eye Prodrug Strategy to Improve Ocular Bioavailability (Nontransporter-Targeted Approach) Recent Patents and Marketed Ocular Prodrugs Novel Formulation Approaches for Sustained Delivery of Prodrugs Conclusion
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147050/
Jul 09, 2014 · Prodrugs are widely used in the targeted delivery of cytotoxic compounds to cancer cells. To date, targeted prodrugs for cancer therapy have achieved great diversity in terms of target selection, activation chemistry, as well as size and physicochemical nature of the prodrug.Author: Irene Giang, Erin L. Boland, Erin L. Boland, Gregory M. K. Poon
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527633166
Dec 15, 2010 · Jarkko Rautio is professor of pharmaceutical chemistry and head of the multidisciplinary Pharmaceutical and Medicinal Chemistry (PMC) research group at the School of Pharmacy, University of Eastern Finland (formerly University of Kuopio), where he received his PhD in …
https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00019
Apr 10, 2019 · Innate and developed resistance mechanisms of bacteria to antibiotics are obstacles in the design of novel drugs. However, antibacterial prodrugs and conjugates have shown promise in circumventing resistance and tolerance mechanisms via directed delivery of antibiotics to the site of infection or to specific species or strains of bacteria. The selective targeting and increased …Author: Ana V. Cheng, William M. Wuest
https://www.amazon.com/Prodrugs-Targeted-Delivery-Towards-Properties/dp/3527326030
Oct 01, 2017 · Prodrugs and Targeted Delivery: Towards Better ADME Properties 1st Edition by Jarkko Rautio (Editor), Raimund Mannhold (Series Editor), Hugo …5/5(2)
https://www.researchgate.net/publication/229954025_Prodrugs_and_Targeted_Delivery_Towards_Better_ADME_Properties
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235738/
Previously, we successfully developed metal-free CO prodrugs by employing the click reaction between cyclopentadienone and a strained alkyne (e.g. BCN). 18 For mitochondrial targeted delivery, we conjugated both components of the Diels-Alder reactants with TPP as the targeting moiety for mitochondria for ETR (Table 3). 49 Additionally, in order ...Author: Yueqin Zheng, Xingyue Ji, Bingchen Yu, Kaili Ji, David Gallo, Eva Csizmadia, Mengyuan Zhu, Manjusha ...
https://vitality.bio/technology/site-specific-delivery/
Cannabosides for Targeted Delivery Reducing Psychoactive THC in Brain to Magnify Pain Relief and Anti-inflammatory Effects. Vitality has developed a new class of cannabinoid prodrugs (cannabosides), which enable selective delivery of THC and cannabidiol (CBD) to the gastrointestinal tract.
https://link.springer.com/chapter/10.1007%2F978-0-387-49785-3_16
Abstract. The liver is the organ in the body primarily responsible for maintaining a continuous supply of glucose, lipids, and other important metabolic substrates to peripheral tissues ().The liver also helps to control the circulating levels of certain amino acids, ketone bodies, free fatty acids, lipoproteins, and some hormones (e.g., insulin, steroids, T 3) and plays an important role in ...Author: Mark D. Erion
https://www.researchgate.net/publication/8372583_Liver-Targeted_Drug_Delivery_Using_HepDirect_Prodrugs
Here we show that a series of phosphate and phosphonate prodrugs, called HepDirect prodrugs, results in liver-targeted drug delivery following a cytochrome P450-catalyzed oxidative cleavage ...
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