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https://pubs.acs.org/doi/abs/10.1021/jm00186a001
Prodrugs and site-specific drug deliveryAuthor: Valentino J. Stella, Kenneth J. Himmelstein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751001/
On the other hand, targeted prodrug design represents a new strategy for directed and efficient drug delivery. Particularly, targeting the prodrugs to a specific enzyme or a specific membrane transporter, or both, has potential as a selective drug delivery system in cancer chemotherapy or …Author: Hyo Kyung Han, Gordon L. Amidon
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751454/
Feb 05, 2008 · The general criteria for site-specific drug delivery through prodrugs can be summarized by the following three criteria; (1) the prodrug must have ready access to the appropriate tissue within the CNS, (2) bioconversion back to the parent drug should be highly site-selective, and (3) the parent drug should exhibit prolonged retention within the ...Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
https://www.sciencedirect.com/science/article/pii/0169409X9500108J
ELSEVIER Advanced Drug Delivery Reviews, 19 (1996) 225-239 advanced drug delivery reviews Review Prodrugs and targeted drug delivery Albert S. Kearney* Pharmaceutical Development, SmithKline Beecham Pharmaceuticals, P.O. Box 1539, UW2922, King of Prussia, PA 19406.Author: Albert S. Kearney
https://www.sciencedirect.com/science/article/pii/S0065774308611781
Chapter 30. Prodrugs and Site-Specific C he mical Delivery Systems Nicholas Bodor University o f Florida, Gainesville, Florida 32610 James J. Kaminski Schering-Plough Corporation, Bloo mfield, New Jersey 07003 Introduction - A number o f r e c e n t review articles and books address various aspects of …Author: Nicholas Bodor, James J. Kaminski
https://www.outsourcedpharma.com/doc/the-emergence-of-prodrugs-a-proficient-pathway-to-new-drug-development-through-the-b-pathway-0001
Apr 04, 2014 · The Emergence Of Prodrugs: A Proficient Pathway To New Drug Development Through The 505(b)(2) Pathway ... Systemic site-specific delivery is one of the ultimate goals in drug delivery and is more complex than local site-specific delivery because the drug is passed through the circulatory system and through multiple membrane barriers to ...
http://www.authorstream.com/Presentation/aSGuest82639-783103-prodrug/
Jan 19, 2011 · Prodrug design is becoming elaborated also in the development of efficient and elective drug delivery systems. Hence prodrugs can be considered as chemical modifications to solve problems associated with pharmacokinetics and site specific delivery of drugs.
https://link.springer.com/chapter/10.1007%2F978-0-387-49785-3_16
Prodrugs and Site-Specific Drug Delivery. J Med Chem 1980; 23:1275–1282 PubMed CrossRef Google Scholar Stephan ZF, Yurachek EC, Sharif R, Wasvary JM, Steele RE, and Howes C. Reduction of Cardioascular and Thyroxine-suppressing Activities of L-T 3 by Liver Targeting with Cholic Acid.Author: Mark D. Erion
https://kuscholarworks.ku.edu/bitstream/handle/1808/8087/Stella_Prodrugs-in-Clinical-Practice_medium.pdf?sequence=1
Prodrugs Do They Have Advantages in Clinical Practice? VJ. Stella, W.N A. Charman and V.H. Naringrekar Department of Pharmaceutical Chemistry, University of Kansas, Lawrence Summary Prodrugs are pharmacologically inactive chemical derivatives of a drug molecule that require a transformation within the body in order to release the active drug ...
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