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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407659/
Sustain drug concentration at desired site is an important feature of ocular delivery. In addition to prolong drug release, sustain delivery formulations can also utilize to prevent drug loss from pre-corneal site. Formulations such as microparticles , nanoparticles [28, 195], and liposomes have been utilized with an aim to delivery prodrug for ...Author: Megha Barot, Mahuya Bagui, Mitan R. Gokulgandhi, Ashim K. Mitra
https://www.researchgate.net/publication/224834657_Prodrug_Strategies_in_Ocular_Drug_Delivery
Prodrug Strategies in Ocular Drug Delivery. ... utilization of prodrug concept in ocular drug delivery. In addition, this review will highlight ongoing academic and industrial research and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
http://europepmc.org/articles/PMC4407659
Jul 01, 2012 · 4. RECENT FORMULATION STRATEGIES FOR OCULAR PRODRUG DELIVERY. Sustain drug concentration at desired site is an important feature of ocular delivery. In addition to prolong drug release, sustain delivery formulations can also utilize to prevent drug loss from pre-corneal site.Author: Megha Barot, Mahuya Bagui, Mitan R. Gokulgandhi, Ashim K. Mitra
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1573-4064&volume=8&issue=4&spage=753
Keywords:Prodrug, transporter, receptor, drug delivery, suspension, ointment, gels, nanoparticles, dendrimers, implants, ophthalmic drugs. Abstract:Poor bioavailability of topically instilled drug is the major concern in the field of ocular drug delivery. Efflux transporters, static and dynamic ocular barriers often possess rate limiting ...
http://samples.jbpub.com/9781284025682/9781449674250_CH10.pdf
eye and various routes of ocular drug administration. Furthermore, this chapter empha-sizes the role of various ocular transporters, prodrug strategies, colloidal dosage forms, implants, contact lens, in situ gelling systems, and other recent developments in drug delivery strategies, including gene therapy. ANATOMY OF THE EYE
https://www.researchgate.net/publication/309383341_Prodrug_Strategy_in_Drug_Development
Prodrug Strategy in Drug Development.pdf ... Apart from of the types of delivery strategies, the composition of the cell membrane is critical for delivery efficiency due to the fact that cellular ...
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527633166
Dec 15, 2010 · This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as ...
https://www.sciencedirect.com/science/article/pii/S135964461300281X
Understanding the basis of prodrug failures is key to the success of chemistry-enabled drug delivery and, like in all other strategies, close collaboration between scientists with different skills and expertise is crucial to determining whether the strategy needs to be abandoned or the properties of the prodrug molecules need to be improved.Author: Sophie-Dorothee Clas, Rosa I. Sanchez, Rebecca Nofsinger
https://www.tandfonline.com/doi/abs/10.1080/17425247.2016.1208649
Aug 05, 2016 · Introduction: Ocular drug delivery is presented with many challenges, taking into account the distinctive structure of the eye.The prodrug approach has been, and is being, employed to overcome such barriers for some drug molecules, utilizing a chemical modification approach rather than a formulation-based approach.Author: Pranjal Taskar, Akshaya Tatke, Soumyajit Majumdar
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