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https://www.researchgate.net/publication/49757618_Prodrug-based_intracellular_delivery_of_anticancer_agents
The strategy is generally based on the conjugation of anticancer prodrugs with tumorsensitive linkers that inhibit prodrug action outside the tumor microenvironment. ...
https://www.sciencedirect.com/science/article/pii/0169409X9500109K
Prodrugs have been used to improve the solubility, transport properties, and pharmacokinetic properties of anticancer agents. More importantly, several prodrug strategies have been developed that enable selective delivery of the cytotoxic agents to the tumor tissue, thereby significantly reducing the toxic side effects of the anticancer agents.
https://pubs.acs.org/doi/10.1021/jm0602155
Nov 08, 2006 · Magnetic responsive of paclitaxel delivery system based on SPION and palmitoyl chitosan. ... Oral delivery of anticancer drugs II: the prodrug strategy. Drug Discovery Today 2013, 18 (1-2) , 93-98. DOI: 10.1016/j.drudis.2012.08.006. ... Toward Smarter Delivery of Anticancer Agents. ChemInform 2007, 38 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147050/
Jul 09, 2014 · Prodrugs are widely used in the targeted delivery of cytotoxic compounds to cancer cells. To date, targeted prodrugs for cancer therapy have achieved great diversity in terms of target selection, activation chemistry, as well as size and physicochemical nature of the prodrug.
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(14)00162-X
Despite the rapid developments in nanotechnology and biomaterials, the efficient delivery of chemotherapeutic agents is still challenging. Prodrug-based nanoassemblies have many advantages as a potent platform for anticancer drug delivery, such as improved drug availability, high drug loading efficiency, resistance to recrystallization upon encapsulation, and spatially and temporally ...
https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.201800030
The authors therefore focuse this mini‐review primarily on single/multistimuli‐responsive prodrugs for cancer therapies, covering prominent examples of prodrug chemistries used to endow polymers with controlled and site‐specific drug delivery properties.
http://iopscience.iop.org/article/10.1088/0957-4484/25/25/255101/pdf
A prodrug strategy based on chitosan for efficient intracellular anticancer drug delivery Cheng Chen, Jiang-Ling Zhou, Xue Han, Fei Song, Xiu-Li Wang and Yu-Zhong Wang Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry,
https://pubs.rsc.org/en/content/articlelanding/2016/tb/c5tb02053k
PEG based anti-cancer drug conjugated prodrug micelles for the delivery of anti-cancer agents Suchithra A. Senevirathne , a Katherine E. Washington , a Michael C. Biewer a and Mihaela C. Stefan * a
https://www.researchgate.net/publication/6171607_Targeted_Sialic_Acid-Doxorubicin_Prodrugs_for_Intracellular_Delivery_and_Cancer_Treatment
Targeted Sialic Acid–Doxorubicin Prodrugs for Intracellular Delivery and Cancer Treatment ... To evaluate a novel targeted anticancer prodrug consisting of several copies of sialic acid (SA ...
https://pubs.acs.org/doi/10.1021/acs.nanolett.7b03531
Therapeutic nanoreactors have been proposed to treat cancers through in situ transformation of low-toxicity prodrugs into toxic therapeutics in the body. However, the in vivo applications are limited by low tissue-specificity and different tissue distributions between sequentially injected nanoreactors and prodrugs. Herein, we construct a block copolymer prodrug-based polymersome nanoreactor ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792284/
Mar 09, 2016 · The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs ... complexes account for another class of pharmacologically active platinum-based anticancer agents. 219 ... anticancer agents is that of a prodrug bearing equatorial ligands identical to those of a platinum(II) complex with established ...
https://www.researchgate.net/publication/5883160_Prodrug_Strategies_in_Anticancer_Chemotherapy
Prodrug Strategies in Anticancer Chemotherapy ... as either microbicides or carriers for intracellular delivery of antiviral drugs. ... promising class of metal-based anticancer agents after the ...
https://www.ncbi.nlm.nih.gov/pubmed/30223045
Oct 28, 2018 · In order to improve the efficacy of chemotherapy for cancers, we have developed a novel prodrug micellar formulation to co-deliver ceramide-generating anticancer agents and ceramide degradation inhibitor (PPMP). The prodrug nanocarrier is based on a well-defined POEG-b-PPPMP diblock copolymer.
https://www.cell.com/trends/pharmacological-sciences/pdf/S0165-6147(14)00162-X.pdf
new trends in the field of prodrug-based nanoas-semblies that enhance the delivery efficiency of antican-cer drugs, with special emphasis on smart stimuli-triggered drugrelease,hybridnanoassemblies,andcom-bination drug therapy. Prodrug and nanoparticulate drug delivery strategies for anticancer drug delivery Although
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978533/
Oct 14, 2009 · In this paper, a new classification system for prodrugs is proposed to provide useful information about where in the body a prodrug is converted to the active drug. In this system, prodrugs are classified into Type I or Type II and the respective Subtypes IA, IB, IIA, IIB or IIC based on their sites of conversion into the final active drug form.
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