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https://www.sciencedirect.com/science/article/pii/S0378517302000546
Floating alginate beads are particularly effective for site-specific controlled release of antibacterial agents effective against harmful stomach bacteria such as H. pylori (Katayama et al., 1999, Whitehead et al., 2000). During formation of the floating drug beads, carbonate salts are reacted with acetic acid to produce carbon dioxide.Author: B. Y. Choi, Hyun Jin Park, S. J. Hwang, J. B. Park
https://www.ncbi.nlm.nih.gov/pubmed/12052693
Jun 04, 2002 · Preparation of alginate beads for floating drug delivery system: effects of CO(2) gas-forming agents. Choi BY(1), Park HJ, Hwang SJ, Park JB. Author information: (1)Graduate School of Biotechnology, Korea University, Seoul 136-701, South Korea.Author: B. Y. Choi, Hyun Jin Park, S. J. Hwang, J. B. Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178975/
A multiple unit oral floating drug delivery system of famotidine was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability. Drug and polymer compatibility was studied by subjecting physical mixtures of drug and polymers to differential scanning calorimetry.
https://www.researchgate.net/publication/11320459_Preparation_of_alginate_beads_for_floating_drug_delivery_system_Effects_of_CO2_gas-forming_agents
Preparation of alginate beads for floating drug delivery system: Effects of CO2 gas-forming agents Article in International Journal of Pharmaceutics 239(1-2):81-91 · July 2002 with 336 Reads
https://www.sciencedirect.com/science/article/pii/S0939641100001107
The floating alginate gel appears to be a promising vehicle for delivering such preparations specifically to the region , . And it will play an important role in therapy of diseases in which a gastric-mucosa-specific drug delivery regimen should be considered, such as H. pylori infection.Author: Y Murata, N Sasaki, E Miyamoto, S Kawashima
https://www.academia.edu/2344742/Preparation_of_alginate_beads_for_floating_drug_delivery_system_effects_of_CO_sub_2_sub_gas-forming_agents
Preparation of alginate beads for floating drug delivery system: effects of CO< sub> 2 gas-forming agents
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