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https://www.sciencedirect.com/science/article/pii/S0022519307004225
We introduced a mathematically rigorous method to calculate the impact of anisotropic and heterogeneous tissue properties on molecular transport in convection enhanced drug delivery. The introduction of DTI to better predict drug transport in the human brain is a first attempt reported in the open literature to the best of our knowledge.Author: Andreas A. Linninger, Mahadevabharath R. Somayaji, Megan Mekarski, Libin Zhang
https://www.researchgate.net/publication/5894485_Prediction_of_convection-enhanced_drug_delivery_to_the_human_brain
Convection-enhanced delivery (CED) is an innovative method of drug delivery to the human brain, that bypasses the blood-brain barrier by injecting the drug directly into the brain.
https://www.ncbi.nlm.nih.gov/pubmed/17950757
Jan 07, 2008 · Prediction of convection-enhanced drug delivery to the human brain. Linninger AA(1), Somayaji MR, Mekarski M, Zhang L. Author information: (1)Laboratory for Product and Process Design, Department of Chemical and Bioengineering, University of Illinois, 851 S. Morgan St. 218 SEO, Chicago, IL 60607, USA. [email protected] <[email protected]>Author: Andreas A. Linninger, Mahadevabharath R. Somayaji, Megan Mekarski, Libin Zhang
https://www.academia.edu/16551437/Prediction_of_convection-enhanced_drug_delivery_to_the_human_brain
The treatment for many neurodegenerative diseases of the central nervous system (CNS) involves the delivery of large molecular weight drugs to the brain. The blood brain barrier, however, prevents many therapeutic molecules from entering the CNS.
https://www.deepdyve.com/lp/elsevier/prediction-of-convection-enhanced-drug-delivery-to-the-human-brain-BBppU1QBIG
Jan 07, 2008 · Read "Prediction of convection-enhanced drug delivery to the human brain, Journal of Theoretical Biology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338487/
Interstitial drug administration via convection-enhanced delivery (CED) is an alternative that potentially overcomes systemic toxicities and CNS delivery issues by directly bypassing the blood–brain …Author: Andrew T. Healy, Michael A. Vogelbaum
https://surgicalneurologyint.com/surgicalint-articles/convection-enhanced-drug-delivery-for-gliomas/
Linninger AA, Somayaji MR, Mekarski M, Zhang L. Prediction of convection-enhanced drug delivery to the human brain. J Theor Biol. 2008. 250: 125-38. 31. Lonser RR, Gogate N, Morrison PF, Wood JD, Oldfield EH. Direct convective delivery of macromolecules to the spinal cord. J …
https://www.sciencedirect.com/science/article/pii/S0168365917310908
Convection enhanced delivery (CED) of chemotherapeutic drugs can successfully bypass the blood-brain barrier (BBB). However, the treatment efficacy is significantly variable in clinic owing to the absence of proper drugs and the lack of understanding on the local drug transport.Author: Wenbo Zhan, Chi-Hwa Wang
https://www.frontiersin.org/articles/10.3389/fonc.2019.00966/full
Thus, the results of a simple method to increase drug delivery may have unintended consequences on tissue morphology. Clinically, prediction of dispersal of agents via convection enhanced delivery is important to catheter design, placement, and implementation to optimize contact of tumor cells with therapeutic agent.Author: Caleb A. Stine, Jennifer M. Munson
https://www.researchgate.net/publication/236910969_Computational_simulation_of_convection-enhanced_drug_delivery_in_the_non-human_primate_brainstem_A_simple_model_predicting_the_drug_distribution
Computational simulation of convection-enhanced drug delivery in the non-human primate brainstem: A simple model predicting the drug distribution Article (PDF Available) in Neurological Research ...
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