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https://www.ondrugdelivery.com/sustained-drug-delivery-posterior-segments-eye/
Drug delivery to the posterior segment of the eye is most efficiently achieved by local, ocular routes of administration, which includes intravitreal, subretinal, suprachoroidal and periocular injections.6,7. Intravitreal injections and implants deliver drugs effectively to the retina and the choroid.
https://www.aao.org/eyenet/article/drug-delivery-for-the-posterior-segment?may-2019
Grewal points to Vitrasert (Chiron, later Bausch + Lomb), the first sustained-release posterior segment drug delivery system that laid some of the foundation for today’s breakthroughs. Approved by the FDA in March 1996, Vitrasert consists of a 4.5 mg pellet of ganciclovir coated with a biocompatible polymer and is designed to deliver the drug over five to eight months.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839363/
Feb 01, 2010 · Treatment of diseases of the posterior segment of the eye, such as age-related macular degeneration, cytomegalovirus retinitis, diabetic retinopathy, posterior uveitis and retinitis pigmentosa, requires novel drug delivery systems that can overcome the many barriers for efficacious delivery of therapeutic drug concentrations.Author: Shalin S Shah, Lori Vidal Denham, Jasmine R Elison, Partha S Bhattacharjee, Christian Clement, Tashf...
https://www.oraclinical.com/resource/ocular-drug-delivery-targeting-the-posterior-segment/
A drug formulation containing penetration enhancers such as gelucires and cyclodextrine microparticles can improve drug partitioning into the corneal epithelium, thus allowing better penetration of the drug through the cornea for more efficient delivery to the posterior segment of the eye.
https://www.sciencedirect.com/science/article/pii/S0753332218306863
Being the most convenient and efficacious non-invasive route, it is the most preferred especially for drug delivery to anterior segment. In general, only 5% of instilled dose reaches anterior chamber [30] and lower than that permeate to posterior segment owing to BRB and BAB.Author: Kritika Nayak, Manju Misra
https://www.sciencedirect.com/science/article/pii/S1359644610008421
Delivery of drugs to the posterior eye is challenging, owing to anatomical and physiological constrains of the eye. There is an increasing need for managing rapidly progressing posterior eye diseases, such as age-related macular degeneration, diabetic retinopathy and retinitis pigmentosa.Author: Thilini Rasika Thrimawithana, Simon Young, Craig Robert Bunt, Colin Green, Raid Ghassan Alany
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