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https://pubs.acs.org/doi/abs/10.1021/ar2002232
Dec 22, 2011 · Synthetic small interfering RNA (siRNA) presents an exciting novel medical opportunity. Although researchers agree that siRNA could have a great therapeutic impact, the required extracellular and intracellular delivery of these molecules into the disease-associated target cells presents the primary roadblock for the broader translation of these molecules into medicines. Thus, the design of ...Author: Ernst Wagner
https://www.researchgate.net/publication/51907954_Polymers_for_siRNA_Delivery_Inspired_by_Viruses_to_be_Targeted_Dynamic_and_Precise
Polymers for siRNA Delivery: Inspired by Viruses to be Targeted, Dynamic, and Precise Article in Accounts of Chemical Research 45(7):1005-13 · December 2011 with 26 Reads How we measure 'reads'Author: Ernst Wagner
https://www.nature.com/articles/ncomms2905
May 21, 2013 · Development of non-viral siRNA delivery systems incorporating the ... delivery vehicles, cationic polymers and lyposomes are ... siRNA using some of the …Author: Nghia P Truong, Wenyi Gu, Wenyi Gu, Indira Prasadam, Zhongfan Jia, Ross Crawford, Yin Xiao, Michael ...
https://pubs.acs.org/doi/10.1021/acscentsci.8b00363
Cytosolic delivery is the major challenge that limits the clinical translation of siRNA-based therapeutics. Although thousands of polymers have been developed for siRNA delivery, the efficiency–toxicity correlation is unsatisfactory. Here, we report a facile strategy to fabricate core–shell-structured nanoparticles with robust siRNA delivery efficiency.Author: Wanwan Shen, Qingwei Wang, Yang Shen, Xiao Gao, Lei Li, Yang Yan, Hui Wang, Yiyun Cheng, Yiyun Cheng
https://link.springer.com/content/pdf/10.1007%2Fs41061-017-0127-6.pdf
Polymers in the Delivery of siRNA for the Treatment of Virus Infections ... Fig. 7 siRNA targeting of DNA and RNA viruses—role of RNA in the viral life cycle. a Positive-sense ... Polymers in the Delivery of siRNA for the Treatment of Virus Infections Author: Nicholas ReynoldsAuthor: Nicholas Reynolds, Megan Dearnley, Tracey M. Hinton
https://www.sciencedirect.com/science/article/pii/S0169409X16302253
3. Virus-inspired nucleic acid delivery systems. Several viruses have been extensively exploited as gene delivery vectors for gene therapy. Besides the recently developed cytoplasmic viral delivery of miRNA, gene transfection and silencing is usually achieved through nuclear delivery of DNA by nuclear viruses.Author: Rong Ni, Junli Zhou, Naushad Hossain, Ying Chau
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