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https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
Dear Colleagues, Gene therapy has been at the forefront of drug delivery research for the past three decades. To overcome the barriers of gene delivery, different types of non-viral delivery systems, including polymers, have been developed and advanced to clinical trials.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079258/
Mar 01, 2011 · Bioreducible polymers, which possess mainly disulfide linkages in the polymer structures, have appeared as ideal gene delivery carriers due to the high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as decreased cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules ...Author: Tae Il Kim, Sung Wan Kim, Sung Wan Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832905/
Oct 17, 2019 · Lack of biodegradation of polymeric gene delivery vehicles poses significant toxicity because of the accumulation of polymers in the tissue. Many attempts have been made to develop biodegradable polymers for gene delivery by modifying existing polymers and/or using natural biodegradable polymers.Author: T. J. Thomas, Heidar-Ali Tajmir-Riahi, C. K. S. Pillai
https://www.sciencedirect.com/science/article/pii/S0168365918301202
Polymers for gene delivery are typically made of cationic monomers that contain primary, secondary, and/or tertiary amine groups that can complex with negatively charged nucleic acid to form condensed polymer-nucleic acid nanoparticle complexes, called “polyplexes” .Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do …Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://www.sciencedirect.com/science/article/pii/S0079670007000718
The first part of this review discusses the current understanding of the various biological barriers that face efficient gene delivery and the rich collection of polymers and design strategies that have accumulated from nearly two decades of intense and prolific research aimed at overcoming these barriers.The second part of this report highlights the challenges that remain and several ...Author: Sharon Y. Wong, Jeisa M. Pelet, David Putnam
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/biopolymer-in-gene-delivery
Various properties such as particle size, surface charge, morphology of the surface and release rate of the loaded molecules are the important parameters in the gene delivery system. In this chapter, various biopolymers (cationic polymers) and inorganic non-viral-delivery vectors used in gene delivery used as therapeutic agents are discussed.Author: Sakthivel Lakshmana Prabu, Kandasamy Ruckmani
https://pubs.acs.org/doi/10.1021/ar200248u
Polymeric gene delivery vectors show great potential for the construction of the ideal gene delivery system. These systems harness their ability to incorporate versatile functional traits to overcome most impediments encountered in gene delivery: from the initial complexation to their target-specific release of the therapeutic nucleic acids at the cytosol. Among the numerous multifunctional ...Author: Sejin Son, Ran Namgung, Jihoon Kim, Kaushik Singha, Won Jong Kim
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
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