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https://www.researchgate.net/publication/51878706_Polymers_for_gene_delivery_Charged_for_success
Polymers for gene delivery: Charged for success. Several researchers are working on the syntheses of DNA-complexated cationic polymers with reduced charge density, high molecular weight and increased hydrophobicity.
https://ui.adsabs.harvard.edu/abs/2012NatMa..11...10M/abstract
Polymers for gene delivery: Charged for success - NASA/ADS DNA-complexated cationic polymers with reduced charge density, high molecular weight and increased hydrophobicity show a lack of detectable cytotoxicity and efficiently deliver the apoptosis-inducing TRAIL gene …Author: Enrico Mastrobattista, Wim E. Hennink
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Gene delivery methods include recombinant viruses and synthetic materials such as lipids, polypeptides and polymers. Safety concerns limit the use of viral vectors. Non-viral gene delivery is typically much safer but suffers from generally unsatisfactory delivery efficiency.Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://www.nature.com/articles/nmat3209
Dec 15, 2011 · DNA-complexated cationic polymers with reduced charge density, high molecular weight and increased hydrophobicity show a lack of detectable cytotoxicity and efficiently deliver the apoptosis-inducing TRAIL gene to transplanted tumours in mice.Author: Enrico Mastrobattista, Wim E. Hennink
https://www.mdpi.com/1420-3049/24/20/3744
Cationic polymers, such as polyethyleneimine are capable of condensing DNA to nanoparticles and facilitate gene delivery. Lack of biodegradation of polymeric gene delivery vehicles poses significant toxicity because of the accumulation of polymers in the tissue.Author: T. J. Thomas, Heidar-Ali Tajmir-Riahi, C. K. S. Pillai
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147627/
Jan 31, 2005 · It introduces the most important cationic polymers used for gene delivery. A transition from in vitro to in vivo gene delivery is also presented, with an emphasis on the obstacles to achieve successful transfection in vivo.Author: H. Eliyahu, Y. Barenholz, A. J. Domb
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