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https://www.researchgate.net/publication/7141587_Nanoparticles_for_Gene_Delivery
Nanoparticles for Gene Delivery. ... Fig. 6.2 shows a classification and a schematic drawing of different types of polymeric nanoparticles used for gene delivery ...
https://dspace.mit.edu/handle/1721.1/44299
However, non-viral gene delivery is currently ineffective. Here, we show that polymeric nanoparticles composed of poly([beta]-amino esters) (PBAEs) and DNA can be formulated to be stable in the presence of serum proteins and have high gene delivery without toxicity to human primary cells.
http://europepmc.org/articles/PMC4319689
Ideally, a gene delivery system should be stable, biocompatible, nontoxic, and capable of high transfection efficiency with specificity. Among the various nonviral gene carriers, nanoparticles (NPs) are an ideal platform that incorporates all desirable characteristics into a single gene delivery system.
https://www.jove.com/video/50176/evaluation-polymeric-gene-delivery-nanoparticles-nanoparticle
Non-viral gene delivery using polymeric nanoparticles has emerged as an attractive approach for gene therapy to treat genetic diseases 1 and as a technology for regenerative medicine 2. Unlike viruses, which have significant safety issues, polymeric nanoparticles can be designed to be non-toxic, non-immunogenic, non-mutagenic, easier to ...
https://www.researchgate.net/publication/23402893_Polymeric_Nanoparticles_for_siRNA_Delivery_and_Gene_Silencing
Polymeric Nanoparticles for siRNA Delivery and Gene Silencing Article in International Journal of Pharmaceutics 367(1-2):195-203 · November 2008 with 152 Reads How we measure 'reads'
https://www.nature.com/articles/s41598-019-39107-3
Polymeric Engineering of Nanoparticles for Highly Efficient Multifunctional Drug Delivery Systems ... Kircheis, R., Wightman, L. & Wagner, E. Design and gene delivery activity of modified ...
https://pubs.acs.org/doi/10.1021/acs.nanolett.9b04981
Combination of chemotherapy and gene therapy provides an effective strategy for cancer treatment. However, lacking of suitable co-delivery systems with efficient endo/lysosomal escape and controllable drug release/gene unpacking is the major bottleneck for maximizing the combinational therapeutic efficacy. Herein, we developed a photoactivatable Pt(IV) prodrug-backboned polymeric nanoparticles ...
https://www.nature.com/articles/nnano.2014.84
May 11, 2014 · Unlike lipid or lipid-like nanoparticles, this formulation does not significantly reduce gene expression in hepatocytes or immune cells even at the dosage necessary for endothelial gene silencing ...
https://www.hindawi.com/journals/jnm/2019/3702518/
In addition to gene delivery, functionalized CNTs can be used as diagnostic tools for the early detection of cancer, ... F. Masood, “Polymeric nanoparticles for targeted drug delivery system for cancer therapy,” Materials Science and Engineering C, vol. 60, pp. 569–578, 2016.
https://www.slideshare.net/shivamthakore/polymeric-nanoparticles-a-novel-approach
Jul 26, 2013 · Polymeric nanoparticles A Novel Approach ... Applications in some areas of medicine Corticoids release Anticancer therapy Crossing BBB Vaccines and gene therapy Diagnostic Ocular delivery 7/26/2013 Department of Pharmaceutical Technology, LJ institute of Pharmacy, Ahmedabad 37 ... “Biodegradable polymeric nanoparticles based drug delivery ...
https://www.onlinelibrary.wiley.com/doi/10.1002/marc.201800917
Polymer nanoparticles have the potential to improve the delivery of therapeutics due to their ability to protect fragile cargo until it reaches a target site. However, there are many biological roadblocks to achieving effective therapeutic delivery. ... Both in vitro and in vivo experiments demonstrated significantly higher gene delivery of the ...
https://www.precisionnanosystems.com/resource-center/publications/detail/microfluidic-generated-lipid-graphene-oxide-nanoparticles-for-gene-delivery
Graphene oxide (GO) is employed in a broad range of biomedical applications including antimicrobial therapies, scaffolds for tissue engineering, and drug delivery, among others. However, the inability to load it efficiently with double-stranded DNA impairs its use as a gene delivery system. To overcome this limitation, in this work, the functionalization of GO with cationic lipids (CL) is ...
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
In 1987, Felgner et al. used the cationic lipid based non-viral gene delivery system for the very first time. This breakthrough opened the opportunity for other non-viral vectors, such as polymers. Cationic polymers have emerged as promising candidates for non-viral gene delivery systems because of their facile synthesis and flexible properties.
https://www.fasebj.org/doi/abs/10.1096/fj.06-7380com
The blood-brain barrier (BBB) poses great difficulties for gene delivery to the brain. To circumvent the BBB, we investigated a novel brain-targeting gene vector based on the nanoscopic high-branch...
https://iopscience.iop.org/article/10.1088/1361-6528/ab313d
The delivery of siRNA using polymeric-based nanoparticles (e.g. PEI) can exhibit severe toxicity towards different cell lines. It was found that the increasing the number of cationic groups or the concentration of the delivery system increased the toxicity level.
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