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https://www.sciencedirect.com/science/article/pii/S0163725806000933
Polymeric micelles, self-assemblies of block copolymers, are promising nanocarrier systems for drug and gene delivery. Until now, several micellar formulations of antitumor drugs have been intensively studied in preclinical and clinical trials, and their utility has been demonstrated.Author: Nobuhiro Nishiyama, Kazunori Kataoka
https://www.sciencedirect.com/topics/materials-science/micelle
3.1.1.1 Polymeric micelles. Polymeric micelles have attracted much attention in drug delivery because of their ability to solubilize hydrophobic molecules, their small particle size, good thermodynamic solution stability, extended release of various drugs, and prevention of rapid clearance by the reticuloendothelial system (RES). Low critical ...
https://www.ncbi.nlm.nih.gov/pubmed/17168771
Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes.Author: S. R. Croy, G. S. Kwon
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690088/
Jun 06, 2009 · 4.2 Polymeric micelles delivering therapeutic genes. For gene delivery directed to clinical application, further developments in carrier design are needed to increase both transgene efficiency and reduce cytotoxicity while maintaining homeostasis.Author: Kensuke Osada, R. James Christie, Kazunori Kataoka
https://pubs.acs.org/doi/10.1021/acsbiomaterials.8b00529
The biodegradable hydrophobic cores should play an important role in gene delivery. However, little research has focused on selectively promoting proliferation and migration of endothelial cells (ECs) as well as vascularization by altering hydrophobic cores of polymeric micelles.Author: Xuefang Hao, Qian Li, Huaning Wang, Khan Muhammad, Jintang Guo, Xiangkui Ren, Changcan Shi, Changcan...
http://www.ijper.org/sites/default/files/IJPER_45_2_4.pdf
Polymeric micelles have gathered considerable attention in the field of drug and gene delivery due to their excellent biocompatibility, low toxicity, enhanced blood circulation time, and ability to solubilize a large number of drugs in their micellar core.
https://pubs.acs.org/doi/abs/10.1021/nl061412u
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via αvβ3 integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core.Author: Norased Nasongkla, Erik Bey, Jimin Ren, Hua Ai, Chalermchai Khemtong, Jagadeesh Setti Guthi, Shook F...
https://www.liebertpub.com/doi/10.1089/10430340460745801
In addition, the types of cells expressing the lacZ gene in the duodenum were identified by histological analysis. DNA/PEO-PPO-PEO polymeric micelles are a single population of rounded micelles with a mean diameter of 170 nm and a ζ potential of -4.3 mV.Author: Shwu Fen Chang, Han Yi Chang, Yaw Chong Tong, Sy Hann Chen, Fei Chin Hsaio, Shao Chun Lu, Jiahorng L...
https://www.researchgate.net/publication/240195792_Smart_polymeric_micelles_for_gene_and_drug_delivery
Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with smart functions ...
https://engineering.jhu.edu/materials/research-projects/polymeric-nanoparticles-for-gene-delivery/
Polymeric Nanoparticles for Gene Delivery. ... Micelles are prepared in distilled water to yield compact nanoparticles, and then oxided to crosslink the core. The disulfide-crosslinked micelles are stable in blood, extracellular milieu and the endolysosomal compartment where the glutathione (GSH) concentration is in the micromolar range ...
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