Polymeric Micelles For Gene Delivery

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Current state, achievements, and future prospects of ...

    https://www.sciencedirect.com/science/article/pii/S0163725806000933
    Polymeric micelles, self-assemblies of block copolymers, are promising nanocarrier systems for drug and gene delivery. Until now, several micellar formulations of antitumor drugs have been intensively studied in preclinical and clinical trials, and their utility has been demonstrated.Author: Nobuhiro Nishiyama, Kazunori Kataoka

Micelle - an overview ScienceDirect Topics

    https://www.sciencedirect.com/topics/materials-science/micelle
    3.1.1.1 Polymeric micelles. Polymeric micelles have attracted much attention in drug delivery because of their ability to solubilize hydrophobic molecules, their small particle size, good thermodynamic solution stability, extended release of various drugs, and prevention of rapid clearance by the reticuloendothelial system (RES). Low critical ...

Polymeric micelles for drug delivery.

    https://www.ncbi.nlm.nih.gov/pubmed/17168771
    Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes.Author: S. R. Croy, G. S. Kwon

Polymeric micelles from poly(ethylene glycol)–poly(amino ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690088/
    Jun 06, 2009 · 4.2 Polymeric micelles delivering therapeutic genes. For gene delivery directed to clinical application, further developments in carrier design are needed to increase both transgene efficiency and reduce cytotoxicity while maintaining homeostasis.Author: Kensuke Osada, R. James Christie, Kazunori Kataoka

CAGW Modified Polymeric Micelles with Different ...

    https://pubs.acs.org/doi/10.1021/acsbiomaterials.8b00529
    The biodegradable hydrophobic cores should play an important role in gene delivery. However, little research has focused on selectively promoting proliferation and migration of endothelial cells (ECs) as well as vascularization by altering hydrophobic cores of polymeric micelles.Author: Xuefang Hao, Qian Li, Huaning Wang, Khan Muhammad, Jintang Guo, Xiangkui Ren, Changcan Shi, Changcan...

Polymeric Micelles: General Considerations and their ...

    http://www.ijper.org/sites/default/files/IJPER_45_2_4.pdf
    Polymeric micelles have gathered considerable attention in the field of drug and gene delivery due to their excellent biocompatibility, low toxicity, enhanced blood circulation time, and ability to solubilize a large number of drugs in their micellar core.

Multifunctional Polymeric Micelles as Cancer-Targeted, MRI ...

    https://pubs.acs.org/doi/abs/10.1021/nl061412u
    We describe the development of multifunctional polymeric micelles with cancer-targeting capability via αvβ3 integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core.Author: Norased Nasongkla, Erik Bey, Jimin Ren, Hua Ai, Chalermchai Khemtong, Jagadeesh Setti Guthi, Shook F...

Nonionic Polymeric Micelles for Oral Gene Delivery In Vivo ...

    https://www.liebertpub.com/doi/10.1089/10430340460745801
    In addition, the types of cells expressing the lacZ gene in the duodenum were identified by histological analysis. DNA/PEO-PPO-PEO polymeric micelles are a single population of rounded micelles with a mean diameter of 170 nm and a ζ potential of -4.3 mV.Author: Shwu Fen Chang, Han Yi Chang, Yaw Chong Tong, Sy Hann Chen, Fei Chin Hsaio, Shao Chun Lu, Jiahorng L...

Smart polymeric micelles for gene and drug delivery ...

    https://www.researchgate.net/publication/240195792_Smart_polymeric_micelles_for_gene_and_drug_delivery
    Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with smart functions ...

Polymeric Nanoparticles for Gene Delivery Materials ...

    https://engineering.jhu.edu/materials/research-projects/polymeric-nanoparticles-for-gene-delivery/
    Polymeric Nanoparticles for Gene Delivery. ... Micelles are prepared in distilled water to yield compact nanoparticles, and then oxided to crosslink the core. The disulfide-crosslinked micelles are stable in blood, extracellular milieu and the endolysosomal compartment where the glutathione (GSH) concentration is in the micromolar range ...

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