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https://www.sciencedirect.com/science/article/pii/S0168365912007596
Another pH-responsive hydrogel device comprising of psyllium and acrylamide/methacrylamide based hydrogels using N,N′-methylenebisacrylamide (N,N′-MBAAm) was studied for oral insulin delivery. This system exhibited dual potential of sustained and controlled release of insulin together with the generation of psyllium after degradation that showed additional glucose lowering effect.Author: Kiran Chaturvedi, Kuntal Ganguly, Mallikarjuna N. Nadagouda, Tejraj M. Aminabhavi
https://www.ncbi.nlm.nih.gov/pubmed/23159827
Jan 28, 2013 · One of the preferred systems widely explored is based on polymeric hydrogels that protect insulin from enzymatic degradation in acidic stomach and delivers effectively in the intestine. Swelling and deswelling mechanisms of the hydrogel under varying pH conditions of the body control the release of insulin.Author: Kiran Chaturvedi, Kuntal Ganguly, Mallikarjuna N. Nadagouda, Tejraj M. Aminabhavi
https://www.researchgate.net/publication/233537196_Polymeric_hydrogels_for_oral_insulin_delivery
The hydrogels formulated from biodegradable, biocompatible, and nontoxic natural polymers were seen as promising devices for potential oral insulin delivery. View Show abstract
https://www.sciencedirect.com/science/article/pii/S0022354916326260
Hydrogels comprised of poly(methacrylic acid) grafted with poly(ethylene glycol) (P(MAA-g-EG)) were characterized and examined for their potential as …Author: Anthony Tuesca, Koji Nakamura, Mariko Morishita, Jeffrey Joseph, Nicholas Peppas, Anthony Lowman
https://www.sciencedirect.com/science/article/pii/S1359644612001237
Natural polymers are generally considered to be safe in vivo, and most of them are already in use as excipients in drug formulations. Nowadays, many natural polymers (polysaccharides and proteins) are being widely investigated as oral insulin delivery carriers (Box 1) by researchers worldwide (Fig.Author: T.A. Sonia, Chandra P. Sharma
https://www.sciencedirect.com/science/article/pii/S1773224706500036
Oral insulin delivery systems based on complexation polymer hydrogels M. Morishita, 1 * [email protected] T. Goto, 1 K. Takayama, 1 N.A. Peppas, 2 1 Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa, Tokyo 142–8501, Japan Department of Pharmaceutics, Hoshi University, Ebara 2-4-41 Shinagawa,...Author: M. Morishita, T. Goto, K. Takayama, Nicholas Peppas
https://onlinelibrary.wiley.com/doi/full/10.1002/marc.201700413
The polymeric encapsulation of oral insulin has already been introduced. 92 The formulation and processing conditions, particle size, protection against gastric acids in the stomach, and controlled‐release at the targeted site are all factors that must be taken into consideration. Most of the oral drug delivery systems developed to date have ...Author: Jing Xie, Anqi Li, Jianshu Li
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