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https://www.ncbi.nlm.nih.gov/pubmed/16715391
Polymer microneedles for controlled-release drug delivery. Park JH(1), Allen MG, Prausnitz MR. Author information: (1)Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.Author: Jung-Hwan Park, Mark G. Allen, Mark R. Prausnitz
https://www.researchgate.net/publication/7067139_Polymer_Microneedles_for_Controlled-Release_Drug_Delivery
As an alternative to hypodermic injection or implantation of controlled-release systems, this study designed and evaluated biodegradable polymer microneedles that encapsulate drug for controlled ...
https://link.springer.com/article/10.1007%2Fs11095-006-0028-9
May 04, 2006 · As an alternative to hypodermic injection or implantation of controlled-release systems, this study designed and evaluated biodegradable polymer microneedles that encapsulate drug for controlled release in skin and are suitable for self-administration by patients. Arrays of microneedles were fabricated out of poly-lactide-co-glycolide using a mold-based technique to encapsulate model drugs ...Author: Jung-Hwan Park, Mark G. Allen, Mark R. Prausnitz
http://drugdelivery.chbe.gatech.edu/Papers/2006/Park%20Pharm%20Res%202006.pdf
controlled release. For rapid release, the model drug was Fig. 1. Controlled-release drug delivery using polymer microneedles. Polymeric controlled release is often achieved by encapsulating drug within microparticles, which are then injected into the body using a hypodermic needle (shown on left). Polymer microneedles can
https://www.sciencedirect.com/science/article/pii/S0168365919305863
3. Controlled microneedle delivery mechanisms 3.1. Controlled release kinetics. Drug release in polymeric MN systems consists of the transportation of drug molecules from the inner polymeric matrix to its outer surface and their further release into the surrounding tissue . Controlling drug-release kinetics is an important approach to ...Author: Parbeen Singh, Andrew Carrier, Yongli Chen, Sujing Lin, Jinlin Wang, Shufen Cui, Xu Zhang
https://www.sciencedirect.com/science/article/pii/S0168365905000568
Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery. ... To test the ability of polymer microneedles to increase transdermal drug delivery, the ability of polymer microneedles to pierce into skin was assessed first. An array of beveled-tip microneedles was inserted into the epidermis of human cadaver skin ...Author: Jung-Hwan Park, Mark G. Allen, Mark R. Prausnitz, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771849/
Sep 04, 2013 · Polymer microneedles for controlled-release delivery are also constrained by needle mechanical properties when the main matrix is PLGA or carboxymethyl cellulose. Park et al found that microneedles with 2% drug loading retained sufficient mechanical …Author: Xiaoyun Hong, Liangming Wei, Fei Wu, Zaozhan Wu, Lizhu Chen, Zhenguo Liu, Weien Yuan
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