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https://www.sciencedirect.com/science/article/pii/S1818087614000725
Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity. These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of applications in drug delivery systems.Author: Jing Li, Xuling Wang, Ting Zhang, Chunling Wang, Zhenjun Huang, Xiang Luo, Yihui Deng
https://www.sciencedirect.com/science/article/pii/S1773224717301119
5.4. In drug delivery systems. Phospholipids based formulations in the drug delivery system can completely alter the absorption of active ingredients through the following mechanisms . • Modification of drug release • Enhance the bioavailability • Modification of the composition and hence the character of the intestinal location •Author: Rudra Pratap Singh, H.V. Gangadharappa, K. Mruthunjaya
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940203/
Jan 01, 2020 · The hydrophobicity and high potency of many therapeutic agents makes them difficult to use effectively in clinical practice. This work focuses on conjugating phospholipid tails (2T) onto podophyllotoxin (P) and its analogue (N) using a linker and characterizing the effects of their incorporation into lipid-based drug delivery vehicles for triggered ultrasound delivery.Author: Mendi G. Márquez, Rachel Dotson, Sally Pias, Liliya V. Frolova, Michaelann S. Tartis
https://www.adcreview.com/news/phospholipid-drug-conjugates-novel-therapeutics-show-promising-results-multiple-myeloma/
Nov 15, 2017 · Phospholipid-Drug Conjugates (PDCs) CLR 131 is built upon Cellectar’s patented delivery and retention platform of optimized phospholipid ether-drug conjugates, or PDCs. The basis for this novel technology relies on the differences between tumor cell plasma membranes from those of healthy cells.Author: Sonia Portillo
https://www.researchgate.net/publication/43248535_Phospholipids_and_Lipid-Based_Formulations_in_Oral_Drug_Delivery
Phospholipids and Lipid-Based Formulations in Oral Drug Delivery. ... semi-liquid and solid lipid-based formulations for drug delivery optimization. ... A phospholipid-drug complex is formed by ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750543/
Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review. ... with some very encouraging results. The improved topical drug delivery has mainly been attributed to the biphasic drug solubility, the desired drug partitioning, and the modification of skin barrier function by the organogel components ...Author: Rajiv Kumar, Om Prakash Katare
https://www.researchgate.net/publication/266380856_Phospholipids_A_Novel_Adjuvant_in_Herbal_Drug_Delivery_Systems
The results of the study concluded that the phospholipid complex may be considered as a promising drug delivery system for improving the absorption and overall bioavailability of the baicalein ...
https://www.cordenpharma.com/apis/lipids-complex-carbohydrates-api-manufacturing/derivatized-phospholipids
Liposomes for Drug Delivery. Since the discovery of liposomes by Bangham and Horne in 1964, the use of phospholipids as critical excipients / pharmaceutical additives or Active Pharmaceutical Ingredients (APIs) in the pharmaceutical and biotech industries is an expanding area.
https://www.adcreview.com/news/phospholipid-ether-drug-conjugates-a-novel-drug-vehicle-delivering-cytotoxic-small-molecules/
May 26, 2016 · Madison (Wisconsin)-based Cellectar Biosciences has been issued a patent for its proprietary drug delivery technology, called phospholipid-ether drug conjugate (PDC). The PDC acts as a cancer targeting drug vehicle delivering cytotoxic small-molecules like paclitaxel, used to treat ovarian, breast, lung, pancreatic and other solid cancers and have demonstrated highly selective uptake and ...Author: Peter Hofland
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