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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830398/
Jan 26, 2010 · In conclusion, a novel acid-responsive Bi(PEG-PLA)-Pt(IV) polymer-cisplatin prodrug conjugate NP was synthesized as a new cisplatin delivery vehicle. The uniqueness of this drug delivery NP system is that the cisplatin analogue prodrug was covalently linked to the hydrophobic segment of two PEG-PLA copolymer chains through pH-sensitive hydrazone bond.Author: Santosh Aryal, Che Ming Jack Hu, Liangfang Zhang
https://pubs.acs.org/doi/abs/10.1021/nn9014032
Dec 29, 2009 · We demonstrate that the synthesized polymer−cisplatin conjugates can readily precipitate to form sub-100 nm NPs in aqueous solution due to their very low critical micelle concentration (CMC). The resulting NPs show well-controlled cisplatin loading yield, excellent acid-responsive drug release kinetics,...Author: Santosh Aryal, Che Ming Jack Hu, Liangfang Zhang
http://pubs.acs.org/doi/pdf/10.1021/nn9014032
Polymer−Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug DeliveryAuthor: Santosh Aryal, Che Ming Jack Hu, Liangfang Zhang
https://pubs.acs.org/doi/pdfplus/10.1021/nn9014032
We demonstrate that the synthesized polymer−cisplatin conjugates can readily precipitate to form sub-100 nm NPs in aqueous solution due to their very low critical micelle concentration (CMC). The resulting NPs show well-controlled cisplatin loading yield, excellent acid-responsive drug release kinetics, and enhanced in vitro cytotoxicity against ovarian cancer cells as compared to free cisplatin.
https://pubs.acs.org/doi/abs/10.1021/nn9014032%40proofing
Polymer−Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug Delivery
https://www.researchgate.net/publication/40811529_Polymer-Cisplatin_Conjugate_Nanoparticles_for_Acid-Responsive_Drug_Delivery
The uniqueness of these drug delivery polymeric NPs lies in the covalent conjugation of each cisplatin drug to the hydrophobic segment of two biocompatible diblock copolymer chains through a ...
https://scholars.houstonmethodist.org/en/publications/polymercisplatin-conjugate-nanoparticles-for-acidresponsive-drug-delivery(5eb9a33e-c4b9-4f77-9a81-d6c413253348).html
Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery Research output : Contribution to journal › Article Santosh Aryal, Che Ming Jack Hu, Liangfang ZhangAuthor: Santosh Aryal, Che Ming Jack Hu, Liangfang Zhang
http://europepmc.org/articles/PMC2830398
Jan 01, 2010 · We demonstrated that these polymer-cisplatin prodrug conjugate NPs had well controlled drug loading yield, excellent acid-responsive drug release characteristics and potent cytotoxicity against ovarian cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379544/
Dec 06, 2010 · First-generation nanoparticles (NPs) have been clinically translated as pharmaceutical drug delivery carriers for their ability to improve on drug tolerability, circulation half-life, and efficacy. Towards the development of the next-generation NPs, researchers have designed novel multifunctional platforms for sustained release, molecular targeting, and environmental responsiveness.Author: Weiwei Gao, Juliana M. Chan, Omid C. Farokhzad
https://www.sciencedirect.com/science/article/pii/S014296121300851X
Because of the broad changes of pH in the human body, pH has become one of the most commonly used stimuli for responsive drug delivery. Compared to the neutral pH in most human tissues, acidic environments are found within the cell in endosomes or lysosomes [21], [22], [23] or in tumor microenvironments [24], [25].Author: Linxian Li, Linxian Li, Zewei Bai, Pavel A. Levkin, Pavel A. Levkin
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