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https://www.researchgate.net/publication/6748197_Polymer-Based_Nanoparticles_for_the_Delivery_of_Nucleoside_Analogues
Polymer-Based Nanoparticles for the Delivery of Nucleoside Analogues Article · Literature Review in Journal of Nanoscience and Nanotechnology 6(9-10):2608-17 · September 2006 with 22 Reads
https://www.ncbi.nlm.nih.gov/pubmed/17048470
Polymer-based nanoparticles for the delivery of nucleoside analogues. ... Nucleoside analogues, together with nucleobases and nucleotide analogues, are commonly used in the treatment of cancer and viral infections. In both cases, they act as antimetabolite agents and interfere with the synthesis of cellular or viral nucleic acids. However, the ...Author: Hervé Hillaireau, Trung Le Doan, Patrick Couvreur
https://www.sciencedirect.com/science/article/pii/S0968089612009522
A system for delivery of analogues of 2′-deoxyribonucleoside triphosphate (dNTP) based on SiO 2 nanoparticles was proposed. A simple and versatile method was developed for the preparation of SiO 2 –dNTP conjugates using the ‘click’-reaction between premodified nanoparticles containing the azido groups and dNTP containing the alkyne-modified γ-phosphate group.Author: Svetlana V. Vasilyeva, Vladimir N. Silnikov, Natalia V. Shatskaya, Asya S. Levina, Marina N. Repkova...
https://www.researchgate.net/publication/7243098_Synthesis_of_nanogel_carriers_for_delivery_of_active_phosphorylated_nucleoside_analogues
According to material of delivery vehicle used for the nanoparticles, they have been categorized as polymer-based nanoparticles, lipid-based nanoparticles, and lipid–polymer hybrid nanoparticles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593126/
Introduction. Nucleoside analogues (NA) and nucleobases are widely used for the treatment of cancer ().For instance, the pyrimidine analogue araC constitutes the cornerstone of induction therapy in patients with acute myeloid leukemia, while the fluorinated pyrimidine analogue gemcitabine has much broader indications, including lung, breast, pancreatic and bladder cancers.Author: Carlos M. Galmarini, Galya Warren, Ekta Kohli, Arin Zeman, Anton Mitin, Serguei V. Vinogradov
https://www.sciencedirect.com/science/article/pii/S0168365906004822
The situation is somewhat different from what is known about unphosphorylated nucleoside analogues. Indeed, the cell capture pattern of AZT when delivered through PACA nanoparticles was found similar to that of free AZT in solution, because unphosphorylated …Author: Hervé Hillaireau, Trung Le Doan, Martine Appel, Patrick Couvreur
https://mct.aacrjournals.org/content/7/10/3373
Oct 01, 2008 · The therapeutic efficiency of anticancer nucleoside analogues (NA) strongly depends on their intracellular accumulation and conversion into 5′-triphosphates. Because active NATP cannot be directly administrated due to instability, we present here a strategy of nanoencapsulation of these active drugs for efficient delivery to tumors. Stable lyophilized formulations of 5′-triphosphates of ...Author: Carlos M. Galmarini, Galya Warren, Ekta Kohli, Arin Zeman, Anton Mitin, Serguei V. Vinogradov
https://www.intechopen.com/books/acrylic-polymers-in-healthcare/synthetic-polymer-based-nanoparticles-intelligent-drug-delivery-systems
1. Introduction. There is no uniform definition of drug delivery systems (DDSs). Generally, a drug delivery system consists of one or more drug compounds, the technology which carries out the drug(s) inside of the body (medical device or dosage form) and the drug-release mechanism [].According to the European Pharmacopoeia (Ph. Eur. 8.0; pg.777), conventional-release (or immediate-release ...Author: Velichka Andonova
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/polymer-nanoparticles-for-smart-drug-delivery
The mechanical strength of polymer based nanocomposites is low due to the poor linkage between nanoparticles and the polymer, which leads to artificial defects in the composites [291-293]. It could be engineered with the appropriate interface to enhance the flexibility, smoothness, strength, stiffness and compatibility of the composite ...Author: Devasier Bennet, Sanghyo Kim
https://www.nature.com/articles/nrd.2017.243
Jan 12, 2018 · mRNA vaccines represent a promising alternative to conventional vaccine approaches, but their application has been hampered by instability …Author: Norbert Pardi, Michael J. Hogan, Frederick W. Porter, Drew Weissman
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