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https://www.ncbi.nlm.nih.gov/pubmed/11987770
Poly-L-lysine-based gene delivery systems. Synthesis, purification, and application. Lollo CP(1), Banaszczyk MG, Mullen PM, Coffin CC, Wu D, Carlo AT, Bassett DL, Gouveia EK, Carlo DJ. Author information: (1)Target Protein Technologies, San Diego, CA, USA. PMID: 11987770 [Indexed for MEDLINE] MeSH terms. Animals; Gene Transfer Techniques ...Author: Charles P. Lollo, Mariusz G. Banaszczyk, Patricia M. Mullen, Christopher C. Coffin, Dongpei Wu, Alis...
https://link.springer.com/protocol/10.1385%2F1-59259-141-8%3A001
Poly-L-Lysine-Based Gene Delivery Systems. Abstract. Nonviral gene delivery has great potential for replacement of recombinant protein therapy. In many cases, gene therapies would be a considerable improvement over existing therapies because of putative advantages in dosing schedule, patient compliance, toxicity, immunogenicity, and cost.Author: Charles P. Lollo, Mariusz G. Banaszczyk, Patricia M. Mullen, Christopher C. Coffin, Dongpei Wu, Alis...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · The synthesis and characterization of poly-L-lysine-based gene delivery systems have been reported . N-terminal modified poly(L-lysine)-antibody conjugate had been used as a carrier for targeted gene delivery in mouse lung endothelial cells .Author: YK Sung, SW Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751499/
Koping-Hoggard M, Tubulekas I, Guan H, et al. Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo.Author: Siddhesh D. Patil, David G. Rhodes, Diane J. Burgess
https://www.sciencedirect.com/science/article/pii/S0045206819312519
synthesis and purification of novel lysine-based dendritic molecules (D3K2, D3G2) ... Despite the numerous research and great interest in the development of an effective delivery system for gene therapy, success in this field has not been achieved so far. ... For the application in gene therapy, ...Author: Michal Gorzkiewicz, Malgorzata Konopka, Anna Janaszewska, Irina I. Tarasenko, Nadezhda N. Sheveleva,...
https://www.sciencedirect.com/science/article/pii/S0960852404003049
This review article deals with the microbial synthesis, physiochemical properties, and potential applications of poly-ε-lysine (ε-PL), which is a naturally occurring biomaterial that is water soluble, biodegradable, edible and non-toxic toward humans and the environment.Author: Ing-Lung Shih, Ming-Haw Shen, Yi-Tsong Van
https://www.sciencedirect.com/science/article/pii/S0142961210013517
Multi-step reactions were performed to synthesize the gene delivery agent, i.e. the ternary copolymer PEG-b -PLL- g-lPEI (PPI), based on PEG, PLL and linear PEI, as showed in Scheme 1. The 1 H NMR spectra of lPEI-OH, Boc-lPEI-OH, PPL and a typical ternary copolymer (PPI3) shown in Fig. S1 (Supplementary information)...Author: Jian Dai, Seyin Zou, Yuanyuan Pei, Du Cheng, Hua Ai, Xintao Shuai
https://link.springer.com/article/10.1208%2Faapsj070109
Mar 01, 2005 · The past several years have witnessed the evolution of gene medicine from an experimental technology into a viable strategy for developing therapeutics for a wide range of human disorders. Numerous prototype DNA-based biopharmaceuticals can now control disease progression by induction and/or inhibition of genes. These potent therapeutics include plasmids containing …Author: Siddhesh D. Patil, David G. Rhodes, Diane J. Burgess
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Cationic Polymer Based Gene Delivery Systems. ... T. Akaike, and A. Maruyama. Synthesis of novel polyampholyte comb-type copolymers consisting of a poly(L-lysine) backbone and hyaluronic acid side chains for a DNA carrier. ... Possibility of application of quaternary chitosan having pendant galactose residues as gene delivery tool. Carbohyd ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://link.springer.com/article/10.1186%2F1556-276X-9-393
Aug 13, 2014 · In the arc discharge deposition and synthesis of CNTs, there are two main different ways: synthesis with use of different catalyst precursors and without use of catalyst precursors. Generally, synthesis of MWNTs could be done without use of catalyst precursors but synthesis of single-wall nanotubes (SWNTs)...Author: Ali Eatemadi, Hadis Daraee, Hamzeh Karimkhanloo, Mohammad Kouhi, Nosratollah Zarghami, Abolfazl Akba...
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