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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678942/
Sep 10, 2008 · Biological activity of Pluronic molecules. The polymers used for drug delivery were considered as biologically inert components that protect drugs from degradation, prolong exposure of drugs to tissues, and enhance transport of drugs into cells.Author: Elena V. Batrakova, Alexander V. Kabanov, Alexander V. Kabanov
https://www.mdpi.com/2079-4983/9/1/11/pdf
Abstract: Poloxamers, also known as Pluronics ... drug delivery for surface modification, the stabilization of colloids and as an excipient to form solid particles [50]. The microphase separation that results in thermodynamically-stable micelles involves two processes [51]. The first process is fast (hundredths-to-tenths of milliseconds) and ...Author: Andrew M. Bodratti, Paschalis Alexandridis
https://www.sciencedirect.com/topics/chemistry/pluronic
Other studies of pluronics involve use of Pluronic F127 for delivery of human growth hormone (Chung et al. 2008), combination of Pluronic F127 with chitosan as an injectable cell delivery carrier for cartilage regeneration (Park et al. 2009), and for enhanced transcription of reporter genes (Sriadibhatla et …
https://www.hcs.harvard.edu/~jus/england.pdf
mediately suits it to protein drug Stabilization and Release Effects of Pluronic F127 in Protein Drug Delivery Jeremy L. England This paper explores the biochemistry of the surfactant hydrogel Pluronic F127 in its capacity as a protein drug delivery mechanism. Computer modeling techniques were used to simulate the behavior
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122590/
Aug 04, 2014 · 2.1. Structure and Function of ABC Transporters. The first drug efflux transporter in cancer cells was described by Juliano and Ling in 1976. 1 They have shown that drug-resistant Chinese hamster ovary cells express a 170 kDa membrane glycoprotein, now known as P-glycoprotein (Pgp, ABCB1), that was unique to the drug-resistant cells. 1 The cells were selected for resistance to …Author: Daria Y. Alakhova, Alexander V. Kabanov
https://www.researchgate.net/publication/267744212_Pluronics_F-127L-81_Binary_Hydrogels_as_Drug-Delivery_Systems_Influence_of_Physicochemical_Aspects_on_Release_Kinetics_and_Cytotoxicity
Pluronics F-127/L-81 Binary Hydrogels as Drug-Delivery Systems: Influence of Physicochemical Aspects on Release Kinetics and Cytotoxicity ... they are of great interest for the development of drug ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/poloxamer
Pluronics are biocompatible and form polymeric micelles with a diameter under 100 nm [154]. Pluronics increase the solubility and modify the pharmacokinetics of poorly soluble drugs [155,156]. Pluronics were also described to overcome multidrug resistance by inhibiting drug efflux transporters such as P-glycoprotein transporters [157–159].
https://hungary.pure.elsevier.com/hu/publications/preparation-and-characterization-of-cationic-pluronic-for-surface
Mar 01, 2016 · Preparation and characterization of cationic pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles G. Gyulai, A. …Author: Gergő Gyulai, Anna Magyar, János Rohonczy, János Orosz, Marcelo Yamasaki, Marcelo Yamasaki, Szilvia ...
https://www.researchgate.net/publication/322590264_Formulation_of_Poloxamers_for_Drug_Delivery
Formulation of Poloxamers for Drug Delivery Andrew M. Bodratti and Paschalis Alexandridis * Department of Chemical and Biological Engineering, University at Buffalo, The State University of New
https://pdfs.semanticscholar.org/50f8/9f12dcd5a3c007032a1b4b7db88061de43f4.pdf
Pluronics in drug delivery applications 2.1. Preparation and structure of Pluronic/drug formulations It is important to prepare Pluronic/drug formulations that can carry higher amounts of drug and also prevent the burst release of drugs once the Pluronics enter the blood stream.
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