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https://www.sciencedirect.com/science/article/pii/S0927776599000636
Plurogel® particles were larger than Pluronic micelles (particle diameter ranged between 30 and 400 nm depending on Pluronic concentration, and type of a gel-forming monomer. This is to be compared to 12–15 nm for Pluronic micelles at 37°C). Plurogel® particle size is advantageous for drug delivery …Author: Natalya Rapoport
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026555/
May 12, 2014 · Structural studies show that pluronic can self-assemble into micelles in aqueous solutions and has aroused wide concern in drug delivery and drug targeting.1–4 In these micelles, the hydrophobic propylene oxide core serves as a “pool” for incorporation of various insoluble compounds, whereas the hydrophilic ethylene oxide shell maintains the micelles in a dispersed state in aqueous solution and avoids renal clearance and nonspecific reticuloendothelial uptake in vivo.5 Several pluronic ...Author: Yanzhi Song, Qingjing Tian, Zhenjun Huang, Di Fan, Zhennan She, Xinrong Liu, Xiaobo Cheng, Bin Yu, Y...
https://www.sciencedirect.com/topics/chemistry/pluronic
The formation of micelles in Pluronics has lead to a plethora of studies in the field of drug delivery. Micelles have a feasible structure for drug loading, since drugs can be incorporated into the core of the micelle at high loads.
https://www.nature.com/articles/srep42465
For the intracellular co-delivery of Pluronic L61 unimers and curcumin in MDR cells, endosomal pH (pH ~5.5)-sensitive micelles conjugated with folate (F-pHSM) were constructed using a copolymer...Author: Wei Hong, Hong Shi, Hong Shi, Mingxi Qiao, Zehui Zhang, Wenting Yang, Lingying Dong, Fucheng Xie, Ch...
https://www.entegris.com/content/en/home/resources/reference-materials/application-notes/appnote-drug-delivery-using-nanoparticles-10549.html
Pluronic P105/L101 Mixed Polymeric Micelles, Pharmaceutical Society of Japan, 128(6), 2008 10Bachar et al., Development and characterization of a novel drug nanocarrier for oral delivery, based on self-assembled b-casein micelles, Journal of Controlled Release, Volume 160, Issue 2, 10 June 2012
https://www.ncbi.nlm.nih.gov/pubmed/17168771
The polymeric micelles used for drug delivery in these examples have shown the abilities to attenuate toxicities, enhance delivery to desired biological sites and improve the therapeutic efficacy of active pharmaceutical ingredients.Author: S. R. Croy, G. S. Kwon
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