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https://www.sciencedirect.com/science/article/pii/S0939641104000475
In this study we prepared poly (d, l-lactide-co-glycolide) (PLGA) nanoparticles bearing polyethyleneimine (PEI) on their surface and characterized them for their potential in serving as non-viral gene carriers to the pulmonary epithelium. Particles that were synthesized at different PLGA–PEI ratios and loaded with DNA in several PEI–DNA ...Author: Maytal Bivas-Benita, Stefan Romeijn, Hans E. Junginger, Gerrit Borchard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667119/
Feb 27, 2009 · Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI) tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including conventional particle-based drug delivery systems, are efficiently trapped in human mucus layers by steric obstruction and/or adhesion.Author: Samuel K. Lai, Ying Ying Wang, Justin S Hanes
https://www.ncbi.nlm.nih.gov/pubmed/19488722
Nonviral gene delivery has been gaining considerable attention recently. Although the efficacy of DNA transfection, which is a major concern, is low in nonviral vector-mediated gene transfer compared with viral ones, nonviral vectors are relatively easy to prepare, less immunogenic and oncogenic, and have no potential of virus recombination and ...Author: Sha Jin, John C. Leach, Kaiming Ye
https://www.researchgate.net/publication/300349752_Protein_Nanoparticles_for_Gene_Delivery
The design of synthetic carriers for nucleic acid delivery has become a research field of increasing interest. Studies on the delivery of DNA have brought up a variety of gene delivery vehicles.
https://link.springer.com/article/10.1007/s41061-017-0128-5
Mar 13, 2017 · Polymeric nanoparticles are more widely used in gene delivery systems than other types of nanoparticles. Their physicochemical properties, such as easy manipulation of particle size, surface charge, and the availability of many functional groups that can be exploited for conjugating different biomolecules and targeting ligands [], make polymeric nanoparticles attractive carriers.Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi, Rajagopal Ramesh
https://www.sciencedirect.com/science/article/pii/S0006291X04007892
Incorporation of biodegradable nanoparticles into human airway epithelium cells—in vitro study of the suitability as a vehicle for drug or gene delivery in pulmonary diseases. Author links open overlay panel M Brzoska a K Langer b C Coester c S Loitsch a T.O.F Wagner a C.v Mallinckrodt a.Author: M Brzoska, K Langer, C Coester, S Loitsch, T.O.F Wagner, C.v Mallinckrodt
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