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https://www.ncbi.nlm.nih.gov/pubmed/27919215
Moreover, PLGA NPs could be modified with different agents to reduce cytotoxicity, to enhance delivery efficiency and to target specific tissues/cells. This review summarizes different methods used for the preparation of PLGA NPs as gene carriers and recent strategies for the modification of PLGA particles applied in gene therapy.Author: Mohammad Ramezani, Mahboubeh Ebrahimian, Maryam Hashemi
https://www.sciencedirect.com/science/article/pii/S0939641104000475
Pulmonary gene delivery is thought to play an important role in treating genetically related diseases and may induce immunity towards pathogens entering the body via the airways. In this study we prepared poly ( d , l -lactide- co -glycolide) (PLGA) nanoparticles bearing polyethyleneimine (PEI) on their surface and characterized them for their ...Author: Maytal Bivas-Benita, Stefan Romeijn, Hans E. Junginger, Gerrit Borchard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832905/
Oct 17, 2019 · 1. Introduction. Gene therapy approaches are under development to treat diseases that arise from genetic abnormalities [1,2,3,4,5].Successful gene therapy requires the efficient delivery of genetic material through the cell membrane into target sites in order to treat these diseases.Author: T. J. Thomas, Heidar-Ali Tajmir-Riahi, C. K. S. Pillai
https://www.sciencedirect.com/topics/neuroscience/plga
Surendra Nimesh, in Gene Therapy: Potential Applications of Nanotechnology, 2013. 15.6 Conclusions. PLGA nanoparticles can improve the therapeutic efficacy of gene delivery due to sustained and controlled release of the encapsulated DNA over a period of days to several weeks compared with natural polymers. Further, PLGA has been approved by the US FDA and the European Medicine Agency in drug ...
https://www.hindawi.com/journals/jnm/2011/952060/
Poly(D,L-lactide-co-glycolide-) (PLGA-)chitosan nanoparticles are becoming an increasingly common choice for the delivery of nucleic acids to cells for various genetic manipulation techniques. These particles are biocompatible, with tunable size and surface properties, possessing an overall positive charge that promotes complex formation with negatively charged nucleic acids. This study ...Author: Hali Bordelon, Alexandru S. Biris, Cristina M. Sabliov, W. Todd Monroe
https://www.hindawi.com/journals/jdd/2012/767839/
Echogenic PLGA nanoparticles are an attractive strategy for ultrasound-mediated gene delivery since this polymer is currently approved by the US Food and Drug Administration for drug delivery and diagnostics in cancer, cardiovascular disease, and also other applications such as vaccines and tissue engineering.Author: Marxa Figueiredo, Rinat Esenaliev
https://pubs.acs.org/doi/abs/10.1021/bm049577p
PLGA: Poloxamer and PLGA: Poloxamine blend nanostructures as carriers for nasal gene delivery. Journal of Controlled Release 2006, 113 (2) , 164-172. DOI: 10.1016/j.jconrel.2006.03.017.. Sustained Release of Water-Soluble Blue Dextran from PLGA Nanoparticles.Author: Noémi Csaba, Pilar Caamaño, Alejandro Sánchez, Fernando Domínguez, María José Alonso
https://nanoscalereslett.springeropen.com/articles/10.1186/1556-276X-6-447
Jul 12, 2011 · The biggest challenge in the field of gene therapy is how to effectively deliver target genes to special cells. This study aimed to develop a new type of poly(D, L-lactide-co-glycolide) (PLGA)-based nanoparticles for gene delivery, which are capable of overcoming the disadvantages of polyethylenimine (PEI)- or cationic liposome-based gene carrier, such as the cytotoxicity induced by excess ...Author: Gao Feng Liang, Yan Liang Zhu, Bo Sun, Fei Hu Hu, Tian Tian, Shu Chun Li, Zhong Dang Xiao
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-016-0081-3
Oct 31, 2016 · Lipid-based surface engineering of PLGA nanoparticles Lipids are hydrophobic or amphiphilic molecules, present in various molecular types such as fatty acids, oils, steroids and waxes [ 20 ]. Among all, glycerophospholipids are the main component of biological membranes, which composed of a glycerol molecule linked to a phosphate group (PO 4 2 ...Author: Rajendran Jc Bose, Soo-Hong Lee, Hansoo Park
https://link.springer.com/article/10.1007/s41061-017-0128-5
Mar 13, 2017 · Polymeric nanoparticles are more widely used in gene delivery systems than other types of nanoparticles. Their physicochemical properties, such as easy manipulation of particle size, surface charge, and the availability of many functional groups that can be exploited for conjugating different biomolecules and targeting ligands [], make polymeric nanoparticles attractive carriers.Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi, Rajagopal Ramesh
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