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https://www.sciencedirect.com/science/article/pii/S0958166918301885
As one of the most important components in the blood stream, platelets could be either harvested from a donor body and re-infused to patients’ circulation after ex vivo engineering or directly hitchhiked by platelet-binding prodrugs and nanoparticles circulating in the blood stream to achieve targeted drug delivery. Moreover, platelet behavior could be mimicked by the recently developed ...Author: Yifei Lu, Quanyin Hu, Chen Jiang, Zhen Gu
https://www.nature.com/articles/srep42632
Feb 15, 2017 · Platelets attracted attention as a potential biological drug delivery system, but the existing studies either mimic the function of platelets or use the platelet membrane to cloak the particles 25 ...Author: Peipei Xu, Huaqin Zuo, Bing Chen, Ruju Wang, Arsalan Ahmed, Yong Hu, Jian Ouyang
https://www.ncbi.nlm.nih.gov/pubmed/30529814
Platelet for drug delivery. Lu Y(1), Hu Q(2), Jiang C(3), Gu Z(4). Author information: (1)Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.Author: Yifei Lu, Quanyin Hu, Chen Jiang, Zhen Gu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376975/
Jan 01, 2012 · In addition, low platelet counts could be used for the delivery of a wide range of therapeutic drugs (Fig. 1C).The drugs evaluated in our study are not tumor specific and thus accumulate in the tumor through passive permeability. 1 Platelet depletion induces breaches in the tumor vasculature enabling more drug to cross the endothelium. In addition to accumulation of a chemotherapeutic drug, …Author: Mélanie Demers, Denisa D. Wagner
https://www.sciencedirect.com/science/article/abs/pii/S0958166918301885
In this Current Opinion, focuses are put on strategies leveraging the physiological functions of platelets for the design of drug delivery systems, including platelet engineering, platelet hitchhiking, membrane coating, synthetic platelet fabrication and platelet-triggered drug release for different applications.Author: Yifei Lu, Quanyin Hu, Chen Jiang, Zhen Gu
https://www.genengnews.com/topics/drug-discovery/immunotherapy-coalesces-on-platelets-as-drug-delivery-mechanism/
Jan 24, 2017 · Immunotherapy Coalesces on Platelets as Drug Delivery Mechanism. January 24, 2017. 0. Share. Facebook. Twitter. ... due to the generation of …
https://news.ncsu.edu/2015/09/gu-platelet-2015/
Sep 29, 2015 · On the left is the schematic design of the TRAIL/Dox loaded platelet membrane-coated nanogel delivery system. The TRAIL is attached on the surface of membrane and Dox is loaded in the core of nanogel. On the right is a transmission electron microscope image of the drug delivery system.
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-019-0494-y
May 13, 2019 · Nanoscale drug-delivery systems (DDSs) have great promise in tumor diagnosis and treatment. Platelet membrane (PLTM) biomimetic DDSs are expected to enhance retention in vivo and escape uptake by macrophages, as well as minimizing immunogenicity, attributing to the CD47 protein in PLTM sends “don’t eat me” signals to macrophages. In addition, P-selectin is overexpressed on the …Author: Haijun Wang, Junzi Wu, Gareth R. Williams, Qing Fan, Shiwei Niu, Jianrong Wu, Xiaotian Xie, Li-Min Z...
http://ijhsonline.com/index.php/archives/finish/6-vol1-issue3/51-platelet-rich-fibrin-prf-gel-as-a-medium-for-local-drug-delivery-of-metronidazole/0
Platelet-Rich Fibrin (PRF) Gel as a Medium for Local Drug Delivery of Metronidazole Tripthi .P.S, et al. 114 INTRODUCTION Among the great challenges facing clinical research is …
https://link.springer.com/article/10.1007%2Fs11095-013-1097-1
Jun 06, 2013 · To develop an efficient biocompatible and targeted drug delivery system in which platelets, an essential blood component having a natural affinity for cancer cells, are used as carrier of anticancer drug as delivery of drug to the targeted site is crucial for cancer treatment. Doxorubicin hydrochloride, a potent anti cancer drug, was delivered in lung adenocarcinoma cell line (A549) using ...Author: Sounik Sarkar, Mohammed Aftab Alam, Jyoti Shaw, Anjan Kr. Dasgupta
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