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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109217/
For the vaccine developer, a consistent story emerging from over 15+ years of clinical development with plasmid based DNA vaccines collected across 100s of human clinical trials covering 1000s of healthy and diseased subjects spanning studies in infectious diseases, cancer, and gene therapy delivery is that of an excellent and consistently ...Author: Niranjan Y Sardesai, David B Weiner
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274812/
Nov 15, 2018 · The high number of DNA-vaccines tested in clinical trials emphasizes their important role for future medical approaches. This review aims to summarize current achievements and ongoing developments in the design of optimized DNA vaccines and delivery methods.Author: Dominika Hobernik, Matthias Bros
https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1154-7
Apr 05, 2019 · Until now, only one therapeutic cancer vaccine has been approved for human use (DC cancer vaccine, Sipuleucel T) [], and most of the other cancer vaccines, including DNA vaccines, are still in clinical phase I or II.New developments in plasmid delivery and optimization and the combination with other therapies aim to improve the efficacy of DNA vaccines in preclinical and clinical studies to ...Author: Alessandra Lopes, Gaëlle Vandermeulen, Véronique Préat
https://www.sciencedirect.com/topics/medicine-and-dentistry/dna-vaccine
DNA vaccines are made of DNA coding sequences that specify the candidate antigen protein inserted into a bacterial plasmid under the regulation of a eukaryotic promoter. DNA vaccines can be administered by multiple routes and can induce virtually all types of immune response: CD8 T-cell cytotoxicity, CD4 T-cell help and antibodies.
https://www.nature.com/articles/s41598-017-04547-2
Jun 23, 2017 · Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques ... F. Electroporation-mediated intradermal delivery of …Author: Biliana Todorova, Lucille Adam, Slobodan Culina, Raphaël Boisgard, Frédéric Martinon, Antonio Cosma,...
https://www.intechopen.com/books/plasmid/plasmid-based-dna-vaccines
In the search for new strategies to prevent infectious diseases, immunization with plasmid-based DNA vaccines was introduced in the clinical field at the beginning of the nineties. Several DNA vaccines have been developed to fight against viral, bacterial, and parasitic diseases.Author: Leonardo A. Gómez, Angel A. Oñate
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