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https://www.ncbi.nlm.nih.gov/pubmed/29151352
Dec 20, 2017 · For silica nanoparticles with rambutan-, raspberry-, and flower-like morphologies composed of spike-, hemisphere-, and bowl-type subunit nanotopographies, respectively, the rambutan-like nanoparticles with spiky surfaces demonstrate the highest plasmid DNA binding capability and transfection efficacy of 88%, higher than those reported for ...Author: Hao Song, Meihua Yu, Yao Lu, Zhengying Gu, Yannan Yang, Min Zhang, Jianye Fu, Chengzhong Yu
https://pubs.acs.org/doi/abs/10.1021/jacs.7b08974
Plasmid DNA molecules with unique loop structures have widespread bioapplications, in many cases relying heavily on delivery vehicles to introduce them into cells and achieve their functions. Herein, we demonstrate that control over delicate nanotopography of silica nanoparticles as plasmid DNA vectors has significant impact on the transfection efficacy.Author: Hao Song, Meihua Yu, Yao Lu, Zhengying Gu, Yannan Yang, Min Zhang, Jianye Fu, Chengzhong Yu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893611/
May 21, 2009 · The cationic gene loaded PLA-PEG nanoparticles was then obtained by adsorbing plasmid DNA onto the surface of cationic PLA-PEG nanoparticles through electrostatic interactions. The physicochemical properties and biological properties of the nanoparticles were investigated and characterized, respectively.Author: Weiwei Zou, Chunxi Liu, Zhijin Chen, Na Zhang
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)38877-3
May 01, 2009 · In Vivo Delivery of Nucleic Acid to the Brain Using DNA Nanoparticles. Open Archive DOI: ... Both DNA nanoparticle formulations were prepared using a plasmid that expresses a luciferase reporter gene. Stereotactic neurosurgery was used to unilaterally inject either the acetate or the trifluoroacetate DNA nanoparticle formulation into the murine ...
https://www.sciencedirect.com/science/article/pii/S0168365920300560
Next, the tumor-targeting capability of RRPHC nanoparticles were evaluated via in vivo imaging and HAC nanoparticles were chose as control. By labelling plasmid with TOTO-3, the sensitive fluorophore that could be used to supervise the position of nanoparticles.Author: Suleixin Yang, Chunqing Ou, Li Wang, Xiaowei Liu, Jin Yang, Xinxin Wang, Meilin Wang, Meiling Shen, ...
https://www.sciencedirect.com/science/article/pii/S1549963416302313
Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizable amino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo.Here we explore the utility of similar LNP systems as transfection reagents for plasmid DNA (pDNA).Author: Jayesh A. Kulkarni, Johnathan Layne Myhre, Sam Chen, Yuen Yi C. Tam, Adrian Danescu, Joy M. Richman,...
https://www.nature.com/articles/nnano.2007.149
Jun 10, 2007 · Bacteria-mediated delivery of nanoparticles and cargo into cells. ... Delivery of a plasmid DNA (coding for GFP) into KB cells using microbots at 3 …Author: Demir Akin, Jennifer Sturgis, Kathy Ragheb, Debby Sherman, Kristin Burkholder, J. Paul. Robinson, Ar...
http://onlinelibrary.wiley.com/doi/10.1002/anie.201301896/full
A small case of love and hate: A block‐statistical copolymer combining reversible hydrophobization and statistical hydrophilization allows the preparation of pH value‐ and reduction‐responsive nanoparticles (polyplexes) for efficient in vivo plasmid delivery.
https://www.hindawi.com/journals/jnt/2014/313415/
The specific targeted delivery of genes to the lung offers the possibility to treat a variety of specific diseases. We developed chitosan nanoparticles with the plasmid pCEM-Luc, which contains a promoter activated by magnetic field.Author: Cynthia Aracely Alvizo Báez, Itza Eloisa Luna Cruz, Maria Cristina Rodríguez Padilla, Juan Manuel Al...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-019-0564-1
Jan 20, 2020 · Cohen et al. found that nanoparticles performed better than liposomes for in vivo delivery of plasmid DNA for gene editing applications, although it did not do as well in in vitro cell studies. Even though we cannot see a clear advantage in using transfecting agents from this particular study, what this result does show is that the encapsulated ...Author: Ami Jo
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