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https://www.sciencedirect.com/science/article/pii/S0168365920301723
Then, we introduce the renal clearable NP-based delivery strategy and discuss how these renal clearable nanocarriers can potentially overcome these physiological barriers for precision drug delivery and clearance, allowing for improved therapeutic index by enhancing both efficacy and safety concurrently.Author: Chuanqi Peng, Yingyu Huang, Jie Zheng
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978509/
Framework of sequential biological barriers to nanoparticle drug delivery. Upon intravenous administration, drug-containing nanoparticles encounter a number of sequential obstacles hindering efficacious, site-specific delivery to tumors. Nanoparticles undergo opsonization and subsequent uptake by resident macrophages of the MPS.Author: Elvin Blanco, Haifa Shen, Haifa Shen, Mauro Ferrari, Mauro Ferrari
https://www.scitusacademics.com/product/drug-delivery-across-physiological-barriers/
Drug Delivery Across Physiological Barriers covers the physiological barriers controlling penetration and transport of substances in the body, strategies for drug penetration across tissue compartments, and drug transport into cells and their compartments.
https://onlinelibrary.wiley.com/doi/10.1002/0471475734.ch2
Mar 11, 2005 · Summary This chapter contains sections titled: Introduction Physiological Barriers to Drug Delivery Biochemical Barriers to Drug Delivery Chemical Barriers to …Author: Anna Maria Calcagno, Teruna J. Siahaan
https://clincancerres.aacrjournals.org/content/5/7/1605
Jul 01, 1999 · Physiological Barriers. There are at least four known physiological barriers to delivery of a blood-borne agent. The first barrier is the heterogeneous angiogenesis and blood flow in tumors. The second barrier is the heterogeneous permeability of tumor vessels.Author: Rakesh K. Jain
https://www.pharmaceutical-journal.com/research/review-article/recent-advances-in-the-oral-delivery-of-biologics/20207374.article
This article summarises the main physiological barriers to oral delivery of biologics and discusses different research strategies to enable, or improve, their oral delivery. The discussion extends to advantages and limitations of these drug delivery strategies and provides perspectives on the potential for clinical translation and the future of ...
https://www.avegaslab.com/research
Overcoming Physiological Barriers The interface of synthetic organic chemistry and drug delivery The Vegas group pursues general and systematic approaches to developing targeted therapeutic carriers for the treatment of multiple human diseases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884307/
Apr 19, 2002 · Part I of this review on pulmonary drug delivery addresses the physiological factors affecting therapeutic effectiveness of inhaled drug therapy, including aerosol particle size, airway geometry, lung clearance mechanisms, and lung disease.Author: N. R. Labiris, M. B. Dolovich
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in the near future. Biomedical engineers have contributed substantially to our understanding of the physiological barriers to efficient drug delivery, such as transport in the circulatory system and drug movement through cells ...
https://www.researchgate.net/publication/283293488_Strategies_of_Overcoming_the_Physiological_Barriers_for_Tumor-Targeted_Nano-Sized_Drug_Delivery_Systems
Strategies of Overcoming the Physiological Barriers for Tumor-Targeted Nano-Sized Drug Delivery Systems Article (PDF Available) in Current Pharmaceutical Design 21(42) · October 2015 with 636 Reads
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