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https://www.ncbi.nlm.nih.gov/pubmed/23099792
Non-viral vectors are preferred for gene therapy, despite lower transfection efficiencies, and possess many customizable attributes that are desirable for tissue engineering applications. However, there is no single non-viral gene delivery strategy that "fits-all" cell types and tissues.Author: Adam Joseph Mellott, M. Laird Forrest, Michael S. Detamore
https://link.springer.com/article/10.1007%2Fs10439-012-0678-1
Oct 26, 2012 · The integration of gene therapy into tissue engineering to control differentiation and direct tissue formation is not a new concept; however, successful delivery of nucleic acids into primary cells, progenitor cells, and stem cells has proven exceptionally challenging. Viral vectors are generally highly effective at delivering nucleic acids to a variety of cell populations, both dividing and ...Author: Adam Joseph Mellott, M. Laird Forrest, Michael S. Detamore
https://kuscholarworks.ku.edu/handle/1808/24064
Non-viral vectors are preferred for gene therapy, despite lower transfection efficiencies, and possess many customizable attributes that are desirable for tissue engineering applications. However, there is no single non-viral gene delivery strategy that “fits-all” cell types and tissues.Author: Adam Joseph Mellott, M. Laird Forrest, Michael S. Detamore
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1402-1
Feb 15, 2018 · Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have ...Author: Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang W...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
https://en.wikipedia.org/wiki/Gene_delivery
Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and also has applications in the genetic modification of crops. There are many different methods of gene delivery for various types of cells and tissues.
https://www.liebertpub.com/doi/10.1089/107632704322791934
Physical Non-Viral Gene Delivery Methods for Tissue Engineering. 26 October 2012 Annals of Biomedical Engineering, Vol. 41, No. 3. ... Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review. Acta Biomaterialia, Vol. 8, No. 4.Author: Kris A. Partridge, Richard O.C. Oreffo
https://www.nature.com/articles/gt201758
Sep 14, 2017 · Recent developments within the field of tissue engineering (TE) have shown that biomaterial scaffold systems can be augmented via the incorporation of gene therapeutics.Author: David P Walsh, Andreas Heise, Andreas Heise, Fergal J O'Brien, Sally-Ann Cryan
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