Ph Controlled Drug Delivery System

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pH Sensitive Drug Delivery Systems: A Review - SciAlert ...

    https://scialert.net/fulltextmobile/?doi=ajdd.2011.24.48
    pH sensitive systems: Controlled drug delivery systems, which are intended to deliver drugs at predetermined rates for predefined periods of time, have been used to overcome the shortcomings of conventional drug formulations. Although, significant progress has been made in the controlled drug delivery area, more advances are yet to be made for treating many clinical disorders, such as …

pH- and ion-sensitive polymers for drug delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
    Having pH-sensitivity, cationic polymers can mask the taste of drugs and release drugs in the stomach by responding to gastric low pH. Anionic polymers responsive to intestinal high pH are used for preventing gastric degradation of drug, colon drug delivery and achieving high bioavailability of weak basic drugs.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako

Controlled Drug Release - an overview ScienceDirect Topics

    https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/controlled-drug-release
    Two types of controlled drug release can be achieved – temporal and distribution control. In temporal control, the aim of the drug delivery system is to deliver the drug over an extended period of time or at a specific duration during treatment.

The Controlled Drug Delivery Systems: Past Forward and ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
    Sep 28, 2014 · The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms.Author: Kinam Park

(PDF) pH Sensitive Drug Delivery Systems: A Review

    https://www.researchgate.net/publication/224937599_pH_Sensitive_Drug_Delivery_Systems_A_Review
    pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance.

Hydrogels: from controlled release to pH-responsive drug ...

    https://www.sciencedirect.com/science/article/pii/S1359644602022559
    A temporally controlled drug delivery system based on pH-oscillators coupled with membrane-diffusion properties has also been proposed . By changing the pH of the solution relative to the drug's p K a value, a drug could be rendered charged or uncharged.Author: Piyush Gupta, Kavita Vermani, Sanjay Garg

Polymers in Controlled Drug Delivery MDDI Online

    https://www.mddionline.com/polymers-controlled-drug-delivery
    Most systems under study for insulin delivery base their delivery on the reaction of glucose in the blood with glucose oxidase, which can be immobilized on polymers within the drug delivery system. The glucose/glucose-oxidase reaction causes a lowering of the pH in the delivery system's microenvironment.

Controlled Release Drug Delivery Systems

    http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/3.1.pdf
    controlled drug delivery applications.Sixty million patients benefit from advanced drug delivery systems today, receiving safer and more effective doses of the medicines they need to fight a variety of human ailments, including cancer. Controlled Drug Delivery (CDD) occurs when a polymer, whether natural or synthetic, is

pH-Activated Targeting Drug Delivery System Based on the ...

    https://pubs.acs.org/doi/abs/10.1021/acsami.6b04737
    May 27, 2016 · pH-Activated Targeting Drug Delivery System Based on the Selective Binding of Phenylboronic AcidAuthor: Dan Zhao, Jia-Qi Xu, Xiao-Qing Yi, Quan Zhang, Si-Xue Cheng, Ren-Xi Zhuo, Feng Li

Colon Targeted Drug Delivery Systems: A Review on Primary ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
    Feb 07, 2010 · The polymers described as pH dependent in colon specific drug delivery are insoluble at low pH levels but become increasingly soluble as pH rises.21 Although a pH dependent polymer can protect a formulation in the stomach, and proximal small intestine, it may start to dissolve in the lower small intestine, and the site-specificity of formulations can be poor.22 The decline in pH from the end …Author: Anil K. Philip, Betty Philip

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