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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410172/
Feb 13, 2019 · Salcaprozate sodium (SNAC) and sodium caprate (C 10) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules.Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over their mechanisms of action.Author: Caroline Twarog, Sarinj Fattah, Joanne Heade, Sam Maher, Elias Fattal, David J. Brayden
https://www.pharmatutor.org/articles/permeation-enhancers-full-introduction
PERMEATION ENHANCERS - FULL INTRODUCTION: A REVIEW . ABOUT AUTHORS: ... The major challenge in the oral drug delivery is the development of novel dosage forms to endorse absorption of poorly permeable drugs across the intestinal epithelium. In this article we reviewed the various permeation enhancers, histology of small intestine, barriers ...
https://www.sciencedirect.com/science/article/pii/S0169409X16301892
Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation enhancement action of over 250 PEs that have been tested in intestinal delivery models.Author: Sam Maher, Randall J. Mrsny, David James Brayden
https://www.sciencedirect.com/science/article/pii/S0168365908001272
Oral drug delivery offers an attractive method of needle-free drug administration. Unfortunately, oral delivery is often hampered by the poor permeability of drugs across the intestinal epithelium. Although several single chemical permeation enhancers have been shown to alleviate permeability difficulties, this often occurs at the expense of ...Author: Kathryn Whitehead, Natalie Karr, Samir Mitragotri
https://www.researchgate.net/publication/5790223_Safe_and_Effective_Permeation_Enhancers_for_Oral_Drug_Delivery
The use of intestinal permeation enhancers to overcome the absorption challenges associated with oral drug delivery has been hampered by the notion that enhancer efficacy is directly linked to ...
https://www.ncbi.nlm.nih.gov/pubmed/18433909
Jun 04, 2008 · Oral drug delivery offers an attractive method of needle-free drug administration. Unfortunately, oral delivery is often hampered by the poor permeability of drugs across the intestinal epithelium. Although several single chemical permeation enhancers have been shown to alleviate permeability difficulties, this often occurs at the expense of ...Author: Kathryn Whitehead, Natalie Karr, Samir Mitragotri
https://ijpsr.com/bft-article/review-article-on-permeation-enhancers-a-major-breakthrough-in-drug-delivery-technology/?view=fulltext
IV. GI Permeation Formulations: Merrion Pharmaceutical is a company which focuses on making drug delivery techniques for easy permeation of present oral disintegrating drugs. Their remedy formulations are collectively called as the gastrointestinal permeation enhancement technology (GIPET).
http://www.americanpharmaceuticalreview.com/pfu/7964385/soids/2277961/Excipient_Search/Permeation_Enhancer
Oral dosing is generally considered to be the most patient-friendly and convenient way to administer medication. However, there are incidents where a pharmaceutical cannot be administered orally due to inadequate oral bioavailability, which may limit the usefulness of a compound.
https://www.mdpi.com/1999-4923/11/1/41/pdf
pharmaceutics Review Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update Sam Maher 1,*, David J. Brayden 2, Luca Casettari 3 and Lisbeth Illum 4 1 School of Pharmacy, Royal College of Surgeons in Ireland, St. Stephens Green, Dublin 2, Ireland 2 School of Veterinary Medicine and UCD Conway Institute, University College Dublin, ...Author: Sam Maher, David J. Brayden, Luca Casettari, Lisbeth Illum
https://www.mdpi.com/1999-4923/11/2/78
Salcaprozate sodium (SNAC) and sodium caprate (C10) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules. Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over their mechanisms of action. C10 acts via openings of epithelial tight junctions and/or membrane ...Author: Caroline Twarog, Sarinj Fattah, Joanne Heade, Sam Maher, Elias Fattal, David J. Brayden
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