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https://www.ncbi.nlm.nih.gov/pubmed/10171149/
In Part II, the authors discuss ideal properties of enhancers and describe various enhancers' actions on the skin, as well as interaction among permeation enhancers and other transdermal delivery system components, such as backing materials, pressure-sensitive adhesives, membranes, and release liners.Author: Pfister Wr, Hsieh Ds
https://www.tandfonline.com/doi/pdf/10.3109/10717544.2014.935532
Today, 74% of drugs are taken orally and are not found to be as effective as desired. To improve such characteristics, transdermal drug delivery was brought to existence. This. delivery system is capable of transporting the drug or macromolecules painlessly through skin. into the blood circulation at …
https://www.sciencedirect.com/science/article/pii/S1818087614000026
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, decreased side effect, easy use and better patient compliance. However, development of transdermal products is primarily hindered by the low permeability of the skin.Author: Yang Chen, Peng Quan, Xiaochang Liu, Manli Wang, Liang Fang
https://www.researchgate.net/publication/12258305_Permeation_Enhancers_for_Transdermal_Drug_Delivery
Terpenes, terpenoids, essential oils, pyrrolidones, fatty acids, fatty acid ester sulfoxides, alcohols, and glycerides have been used as permeation enhancers for transdermal drug delivery and can help overcome the barrier properties of the stratum corneum.
http://www.bioline.org.br/pdf?pr09023
Transdermal drug delivery is the administration of a therapeutic agent through intact skin for systemic effect. Transdermal drug delivery offers the following advantages over the oral route for controlled drug delivery 3. • Avoidance of hepatic first pass metabolism. • Ability to discontinue administration by removal of the system.
https://biomeddermatol.biomedcentral.com/articles/10.1186/s41702-020-0058-7
This review summarizes the advances in the development and mechanisms of action of chemical components that act as permeation enhancers, as well as the advances in appropriate vehicles, such as gels, emulsions, and vesicular delivery systems, that can be used for effective transdermal delivery.
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