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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410172/
Feb 13, 2019 · Salcaprozate sodium (SNAC) and sodium caprate (C 10) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules.Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over their mechanisms of action.Author: Caroline Twarog, Sarinj Fattah, Joanne Heade, Sam Maher, Elias Fattal, David J. Brayden
https://www.pharmatutor.org/articles/permeation-enhancers-full-introduction
Delivery of a drug by oral route is predominantly restricted by pre-systemic degradation and poor penetration across the gut wall. The major challenge in the oral drug delivery is the development of novel dosage forms to endorse absorption of poorly permeable drugs across the intestinal epithelium.
https://www.sciencedirect.com/science/article/pii/S0168365908001272
Discovery of synergistic permeation enhancers for oral drug delivery 1. Introduction. Oral delivery is one of the most-sought after types of drug administration,... 2. Materials and methods. One enhancer was selected from each of 11 distinct chemical categories... 3. Results. A schematic of the ...Author: Kathryn Whitehead, Natalie Karr, Samir Mitragotri
https://www.researchgate.net/publication/5790223_Safe_and_Effective_Permeation_Enhancers_for_Oral_Drug_Delivery
The use of intestinal permeation enhancers to overcome the absorption challenges associated with oral drug delivery has been hampered by the notion that enhancer efficacy is directly linked to toxicity. This study attempts to gain insight into the principles governing the potency and toxicity behavior of enhancers.
https://www.ncbi.nlm.nih.gov/pubmed/18433909
Jun 04, 2008 · Oral drug delivery offers an attractive method of needle-free drug administration. Unfortunately, oral delivery is often hampered by the poor permeability of drugs across the intestinal epithelium. Although several single chemical permeation enhancers have been shown to alleviate permeability difficulties, this often occurs at the expense of safety.Author: Kathryn Whitehead, Natalie Karr, Samir Mitragotri
https://www.sciencedirect.com/science/article/pii/S0169409X16301892
Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation enhancement action of over 250 PEs that have been tested in intestinal delivery models.Author: Sam Maher, Randall J. Mrsny, David James Brayden
https://www.ncbi.nlm.nih.gov/pubmed/19663558
A clinically accepted permeation enhancer must increase membrane permeability without causing toxicity and permanent membrane damage. To date, the information available on oral mucosal permeation enhancement is much less than transdermal enhancement, though oral mucosa is more resistant to damage than other mucosal membranes.Author: Harmik Sohi, Alka Ahuja, Farhan Jalees Ahmad, Roop Krishen Khar
https://ijpsr.com/bft-article/review-article-on-permeation-enhancers-a-major-breakthrough-in-drug-delivery-technology/?view=fulltext
GI Permeation Formulations: Merrion Pharmaceutical is a company which focuses on making drug delivery techniques for easy permeation of present oral disintegrating drugs. Their remedy formulations are collectively called as the gastrointestinal permeation enhancement technology (GIPET).
https://www.sciencedirect.com/science/article/pii/S1818087614000026
The paper has given an overview of the investigations on the design of novel permeation enhancers for transdermal drug delivery systems. The list of these materials in the paper is clearly not exhaustive, but represents the general strategies involving in the identification of agents that can facilitate drug delivery through the skin barrier.Author: Yang Chen, Peng Quan, Xiaochang Liu, Manli Wang, Liang Fang
http://www.ijprr.com/File_Folder/33-40.pdf
permeation collected data; penetration enhancers may disrupt the packing of intercellular lipid matrix, increasing drug partitioning into the tissue or intracellular keratin domains by acting as a solvent for the drug within the membrane.
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