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https://www.sciencedirect.com/science/article/pii/S1359644602024522
Nasal drug delivery has generated widespread interest among the scientific community as an alternative route for the administration of drugs and biomolecules that are susceptible to enzymatic or acidic degradation and first-pass hepatic metabolism . This can be attributed to the high vascularity and the permeability of the nasal mucosa, which aids the drug in bypassing the aforementioned processes …Author: Priyanka Arora, Shringi Sharma, Sanjay Garg
https://www.researchgate.net/publication/10934101_Permeability_issues_in_nasal_drug_delivery
In vivo, the MCC, and the mucus layer itself are for nasal drug delivery one of the limiting factors resulting in impeded drug permeability [11, 24]. Mucus is of utmost importance, since the ciliated cells transport the mucus to nasopharynx in order to remove foreign particles [26]. ...
https://www.academia.edu/8228273/Permeability_issues_in_nasal_drug_delivery
Permeability issues in nasal drug delivery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581654/
In vitro experiments have also been used to investigate transport pathway-, metabolism-, and formulation-related issues . Permeability is a primary determinant of the extent of absorption for compounds without solubility limitations . The systemic concentration of a drug is determined by its absorption and clearance rates, but typically the absorption rate is best related to the permeability value because they both represent the successful passage of the drug …Author: Hefei Zhang, Chih-Wei Lin, Maureen D. Donovan
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
Further experiments are needed to establish a robust correlation between the properties of the compound being investigated, the physiology of the nasal cavity, and the impact of specialized drug delivery techniques that are known to influence drug delivery to the brain via the nasal route of administration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649785/
PHYSIOLOGICAL FEATURES OF THE NASAL AND ORAL MUCOSA AFFECTING PERMEABILITY OF DRUG Nasal cavity has been used from ancient time as a drug delivery route to alleviate diseases and disorders. One of the ‘ panchakarmas ’ stated in Ayurveda is ‘ nasyakarma ’, a practice in which a drug is administered through the nostrils[ 9 ].
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