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https://www.sciencedirect.com/science/article/pii/B9780124160200000103
Chapter 10 - Peptide Nanoparticles for Oligonucleotide Delivery. In the past two decades, different methods have emerged for intervention with gene expression, which can be generally referred to as gene therapy. Oligonucleotides (ONs) and their analogs form the basis of the molecules that can be used to modulate gene expression.Author: Taavi Lehto, Kariem Ezzat, Ülo Langel, Ülo Langel
https://www.researchgate.net/publication/51809997_Peptide_Nanoparticles_for_Oligonucleotide_Delivery
Cell-penetrating peptides (CPPs) are short cationic peptides that have been extensively studied as drug delivery vehicles for proteins, nucleic acids and nanoparticles.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376484/
Apr 01, 2015 · One such system involves cationic peptide delivery vehicles, often referred to as cell-penetrating peptides (CPPs) or peptide transduction domains . They were first introduced in 1994 [ 5 ], and since then there has been a constant stream of new delivery peptides with increased delivery efficiency and better pharmacological properties in several applications.Author: Peter Järver, Eman M. Zaghloul, Andrey A. Arzumanov, Amer F. Saleh, Graham McClorey, Suzan M. Hammon...
https://www.sciencedirect.com/science/article/pii/S0196978114001314
The stearylation of amphipathic peptides (RXR)4 and (TP10) had a remarkable impact on the delivery efficiency of oligonucleotides partially by promoting endosomal escape. In a research work has been investigated whether stearyl-TP10 could be used for the delivery of plasmids as well.Author: Samad Mussa Farkhani, Alireza Valizadeh, Hadi Karami, Samane Mohammadi, Nasrin Sohrabi, Fariba Badrz...
https://en.wikipedia.org/wiki/Nanoparticles_for_drug_delivery_to_the_brain
Background. The first successful delivery of a drug across the BBB occurred in 2005. The drug used was hexapeptide dalargin, an anti-nociceptive peptide that cannot cross the BBB alone. It was encapsulated in polysorbate 80 coated nanoparticles and intravenously injected. This was a huge breakthrough in the nanoparticle drug delivery field, and it helped advance research and development toward ...
https://www.pnas.org/content/105/45/17222
Nov 11, 2008 · If the oligonucleotide concentration in solution is held constant (1.7 nmol/ml), an increase in peptide concentration results in a nanoparticle conjugate with an increased peptide loading and a decreased oligonucleotide loading.Author: Pinal C. Patel, David A. Giljohann, Dwight S. Seferos, Chad A. Mirkin
https://www.sciencedirect.com/science/article/pii/S0169409X11002316
Gold nanoparticles (AuNPs) provide attractive vehicles for delivery of drugs, genetic materials, proteins, and small molecules. AuNPs feature low core toxicity coupled with the ability to parametrically control particle size and surface properties.Author: Subinoy Rana, Avinash Bajaj, Rubul Mout, Vincent M. Rotello
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964096/
Mar 18, 2014 · Recent reports have demonstrated delivery of cholesterol-modified siRNA via lipoprotein-based materials (15, 18). Amino acids and peptides are natural building blocks of apolipoproteins, and previous studies have examined the potential of amino acid derivatives for gene delivery or siRNA delivery (19 –24). However, to our knowledge, none of ...Author: Yizhou Dong, Yizhou Dong, Kevin T. Love, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yu...
https://www.sciencedirect.com/science/article/pii/S1387181120302031
Apr 10, 2020 · Hierarchical mesoporous carbon (MPC) nanomaterials derived from the carbonized chitosan (CTS) encapsulated zeolitic imidazolate frameworks (ZIF-8) is …
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