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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032848/
Dec 17, 2013 · RGENs consist of two components: Cas9 protein and guide RNA. Plasmid-mediated delivery of these components into cells can result in uncontrolled integration of the plasmid sequence into the host genome, and unwanted immune responses and potential safety problems that can be caused by the bacterial sequences.Author: Suresh Ramakrishna, Abu-Bonsrah Kwaku Dad, Jagadish Beloor, Ramu Gopalappa, Sang-Kyung Lee, Hyongbum...
http://pubs.acs.org/doi/abs/10.1021/bc960079q
Peptide-Mediated Gene Delivery: Influence of Peptide Structure on Gene Expression. Abstract. Cationic peptides possessing a single cysteine, tryptophan, and lysine repeat were synthesized to define the minimal peptide length needed to mediate transient gene expression in mammalian cells.
https://pubs.acs.org/doi/10.1021/bc960079q
Efficient Gene Delivery by a Peptide Derived from a Monoclonal anti-DNA Antibody. Bioconjugate Chemistry 1999, 10 (1) , 87-93. DOI: 10.1021/bc980081c. Lev Bromberg and, Gideon Levin. Poly(amino acid)-b-Poly(N,N-diethylacrylamide)-b-Poly(amino acid) Conjugates of Well-Defined Structure.Author: Manpreet S. Wadhwa, Wendy T. Collard, Roger C. Adami, Donald L. McKenzie, Kevin G. Rice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790891/
In general, the VTW peptide facilitated the transfection of PEI nanoparticles into U-87 cells via receptor-mediated uptake, while it reduced the cytotoxicity (Figure 4) due to less residual positive charge on the surface of the nanoparticles.Author: Chuanwei Wang, Liping Ning, Hongwei Wang, Zaijun Lu, Xingang Li, Xiaoyong Fan, Xuping Wang, Yuguang ...
https://www.sciencedirect.com/science/article/pii/S2162253119303051
Receptor-mediated delivery of nucleic acids to tumor cells is an important issue in the development of viral and synthetic gene delivery systems. Besides increased accumulation in tumors when delivered systemically, their improved internalization into target cells via transfection-permissive uptake routes allows to significantly increase transfection rates and transgene expression.Author: Alexander Taschauer, Wolfram Polzer, Fatih Alioglu, Magdalena Billerhart, Simon Decker, Theresa Kitt...
https://www.sciencedirect.com/science/article/pii/S0939641119300797
Peptide-mediated delivery of therapeutic mRNA in ovarian cancer Author links open overlay panel Dirk van den Brand a b Mark A.J. Gorris c Alexander H. van Asbeck a 1 Emma Palmen a Inge Ebisch d Harry Dolstra e Mattias Hällbrink f Leon F.A.G. Massuger b Roland Brock aAuthor: Dirk van den Brand, Mark A.J. Gorris, Alexander H. van Asbeck, Emma Palmen, Inge Ebisch, Harry Dolst...
https://www.ncbi.nlm.nih.gov/pubmed/27832534/
Cell-penetrating peptide (CPP), a peptide that has an intrinsic ability to translocate across cell membranes, has been adopted as a means of achieving efficient Cas9 protein and guide RNA delivery. We developed a method for treating human cell lines with CPP-conjugated recombinant Cas9 protein and CPP-complexed guide RNAs that leads to endogenous gene disruption.Author: Bharathi Suresh, Suresh Ramakrishna, Hyongbum Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896395/
Jan 20, 2014 · These modifications are reversible under reducing conditions and enabled TALEN-mediated gene knockout of the human CCR5 and BMPR1A genes at rates comparable to those achieved with transient transfection of TALEN expression vectors. These findings demonstrate that direct protein delivery, facilitated by conjugation of chemical functionalities onto the TALEN protein surface, is a promising alternative to current non-viral and viral-based methods for TALEN delivery …Author: Jia Liu, Thomas Gaj, James T. Patterson, Shannon J. Sirk, Carlos F. Barbas
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