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https://www.researchgate.net/publication/10690760_Peptide-mediated_cellular_delivery_of_antisense_oligonucleotides_and_their_analogues
Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues Article · Literature Review (PDF Available) in Cellular and Molecular Life Sciences CMLS 60(5):844-53 · June ...
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30083-X.pdf
cal and toxicological aspects of peptide-mediated delivery. Developments towards clinical use are also highlighted, with particular emphasis on peptide conjugates of oligonucleotide analogues used for treatment of neuromuscular diseases. INTRODUCTION Antisense oligonucleotides are used widely to …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390225/
Jun 12, 2012 · Strategies For Peptide-Mediated Delivery. There are two main ways of utilizing peptide vectors for the delivery of antisense oligonucleotides and siRNA. The first method involves chemical synthesis of peptides that are modified to enable covalent conjugation to oligonucleotides or other cargo types (Figure 3a). Such conjugation reactions may be ...Author: Peter Järver, Thibault Coursindel, Samir El Andaloussi, Samir El Andaloussi, Caroline Godfrey, Matth...
https://www.cell.com/molecular-therapy-family/nucleic-acids/references/S2162-2531(16)30083-X
Jan 01, 2012 · This review begins by describing the modes of action of antisense reagents and siRNA and goes on to focus on recent advances in their peptide-mediated cell and in vivo delivery and how peptide use has influenced drug development. The review discusses the challenges associated with understanding the physiological and toxicological aspects of ...Author: Peter Järver, Thibault Coursindel, Samir El Andaloussi, Samir El Andaloussi, Caroline Godfrey, Matth...
https://www.researchgate.net/publication/259114594_Cellular_Delivery_of_Peptide_Nucleic_Acids_PNAs
Cellular Delivery of Peptide Nucleic Acids (PNAs) ... delivery of antisense oligonucleotides and their ... belong to the next generation of synthetic nucleic acid analogues. Their high binding ...
https://www.sciencedirect.com/science/article/pii/S1079979606002038
RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA ... Synthetic oligonucleotides and their analogues and small interfering RNA ... M.J. GaitPeptide-mediated cellular delivery of antisense oligonucleotides and their analogues. Cell. Mol. Life Sci., 60 (2003), pp. 1-10.Author: John J. Turner, Simon Jones, Martin M. Fabani, Gabriela Ivanova, Andrey A. Arzumanov, Michael J. Gai...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778081/
The focus of this article is recent progress in the field of peptide-mediated cellular delivery of siRNA and steric block oligonucleotides in cell tissue culture as a starting point for further developments illustrated by own experimental data.Author: S.D Laufer, T Restle
https://www.biosyn.com/dna-peptide-conjugates.aspx
Contact our Technical Service Center at 800.227.0627 or contact us online with detailed oligo-peptide project specifications. A project manager will be assigned to help you to design an appropriate synthetic method for your specific needs. References. 1. Gait, M.J. Peptide-mediated cellular delivery of antisense oligonucleotides and their ...
https://link.springer.com/protocol/10.1385%2F1-59259-823-4%3A205
Methods of peptide-oligonucleotide conjugate synthesis are presented that may be useful in the study of cell targeting and delivery of oligonucleotides and their analogs. The first method involves total stepwise solid-phase synthesis on a single support.Author: Dmitry A. Stetsenko, Michael J. Gait
https://www.liebertpub.com/doi/full/10.1089/nat.2018.0747
Feb 04, 2019 · Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues. Cell Mol Life Sci 60:844–853. Crossref, Medline, Google Scholar; 26. Richard JP, Melikov K, Vivès E, Ramos C, Verbeure B, Gait MJ, Chernomordik LV and Lebleu B. (2003). Cell-penetrating peptides. A re-evaluation of the mechanism of cellular uptake.Author: M J Gait, A A Arzumanov, G McClorey, C Godfrey, C Betts, S Hammond, Wood Mja.
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