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https://pubs.acs.org/doi/abs/10.1021/mp400680d
Neurological diseases such as neurodegeneration, pain, psychiatric disorders, stroke, and brain cancers would greatly benefit from the use of highly potent and specific peptide pharmaceuticals. Peptides are especially desirable because of their low inherent toxicity. The presence of the blood brain barrier (BBB), their short duration of action, and their need for parenteral administration ...Author: Aikaterini Lalatsa, Andreas G. Schatzlein, Ijeoma F. Uchegbu
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Olanzapine, when loaded onto PLGA nanoparticles, resulted in delivery to the brain that was 10 times more efficient than nose-to-brain delivery with olanzapine solution, resulting in a C max of 0.049% of the dose and a C max of 0.0045% of the dose with the nanoparticle and solution formulations, respectively (Seju et al., 2011).Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.sciencedirect.com/science/article/pii/B9780123849359100069
This chapter highlights the significant advances in brain delivery of peptide and protein drugs made over the past three decades. While many limitations still exist regarding the cerebral delivery of peptide and protein drugs, several strategies show considerable promise for improvement of brain uptake.Author: Christine Dufès
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931241/
Jun 28, 2016 · Traumatic brain injury (TBI) is a major health and socio-economic problem, but no pharmacological agent is currently approved for the treatment of acute TBI. Thus, there is a great need for advances in this field. Here, we describe a short peptide (sequence ...Author: Aman P. Mann, Pablo Scodeller, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Jinmyoung Joo, Ester K...
https://www.sciencedirect.com/science/article/pii/S0968089617317273
Nose-to-brain (N-to-B) delivery offers to protein and peptide drugs the possibility to reach the brain in a non-invasive way. This article is a comprehensive review of the state-of-the-art of this emerging peptide delivery route, as well as of the challenges associated to it.Author: Eleni Samaridou, Maria José Alonso
https://www.nature.com/articles/ncomms11980
Jun 28, 2016 · Traumatic brain injury (TBI) is a major health and socio-economic problem, but no pharmacological agent is currently approved for the treatment of acute …Author: Aman P. Mann, Pablo Scodeller, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Jinmyoung Joo, Ester K...
https://www.ncbi.nlm.nih.gov/pubmed/18270319
Delivery of galanin-like peptide to the brain: targeting with intranasal delivery and cyclodextrins. ... These studies show that intranasal administration is an effective route of administration for the delivery of GALP to the brain and that targeting among brain regions may be possible with the use of various cyclodextrins.Author: Naoko Nonaka, Susan A. Farr, Haruaki Kageyama, Seiji Shioda, William A. Banks
https://www.nature.com/articles/s41598-018-36210-9
Dec 05, 2018 · In a recent study, we demonstrated the potential of a cell-penetrating peptide (CPP) penetratin to deliver the peptide drug insulin to the brain via nasal administration, and its …Author: Noriyasu Kamei, Nobuyuki Okada, Takamasa Ikeda, Hayoung Choi, Yui Fujiwara, Haruka Okumura, Mariko T...
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