Peptide Delivery Liposomes

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Lipid-based colloidal carriers for peptide and protein ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676808/
    Considering a future application of these systems for peptide or protein delivery, for most biomacromolecules a parenteral application is inevitable. For that reason, the cytotoxicity of liposomes and lipid nanoparticles is an essential product parameter with regard to a prospective in vivo tolerance evaluation in humans and/or animals.Author: Susana Martins, Bruno Sarmento, Domingos C Ferreira, Eliana B Souto

Liposomal delivery of proteins and peptides.

    https://www.ncbi.nlm.nih.gov/pubmed/23092138
    Liposomal delivery of proteins and peptides. ... One of the common approaches to overcome these issues is the use of a carrier and liposomes as carriers have been investigated extensively over the last decade. ... as carriers for delivery of biopharmaceutical moieties and scrutinises the aspects behind the absence of a protein/peptide ...Author: Janani Swaminathan, Carsten Ehrhardt

Drug delivery using polyhistidine peptide-modified ...

    https://www.sciencedirect.com/science/article/pii/S0006291X18310866
    For example, TAT peptide-modified liposomes and R8 peptide-modified liposomes have been reported as typical CPP-modified liposomes. These CPP-modified liposomes are internalized into the cell via the endocytosis pathway [8,9]. Moreover, CPP-modified liposomes have been widely studied as DDSs.Author: Taiki Hayashi, Matsumi Shinagawa, Tsuyoshi Kawano, Takashi Iwasaki

Cell penetrating peptide conjugated liposomes as ...

    https://www.sciencedirect.com/science/article/pii/S037851731500054X
    In this study, Polygonum aviculare L. extract, which has superior antioxidative and cellular membrane protective activity, was loaded onto cell penetrating peptide (CPP) conjugated liposomes to enhance transdermal delivery. The physical characteristics of typical liposomes and CPP-conjugated liposomes containing P. aviculare extract were evaluated. The particle sizes of both liposomes were ...Author: Soon Sik Kwon, Sun Young Kim, Bong Ju Kong, Kyeong Jin Kim, Geun Young Noh, Na Ri Im, Ji Won Lim, Ji...

Peptide-Mediated Liposomal Drug Delivery System Targeting ...

    https://www.hindawi.com/journals/jo/2010/723798/
    These anti-angiogenic drug delivery systems could be used to target both tumor blood vessels as well as the tumor cells, themselves. This article reviews the mechanisms and advantages of various present and potential methods using peptide-conjugated liposomes to specifically destroy tumor blood vessels in anticancer therapy.Author: Han-Chung Wu, De-Kuan Chang

TAT peptide on the surface of liposomes affords their ...

    https://www.pnas.org/content/98/15/8786
    Jul 17, 2001 · To achieve an efficient intracellular drug and DNA delivery, attempts were made to target microparticulate drug carriers into cytoplasm bypassing the endocytotic pathway. TAT peptides derived from the HIV-1 TAT protein facilitate intracellular delivery of proteins and small colloidal particles. We demonstrated that relatively large drug carriers, such as 200-nm liposomes, can also be delivered ...Author: Vladimir P. Torchilin, Ram Rammohan, Volkmar Weissig, Tatyana S. Levchenko

Liposome - Wikipedia

    https://en.wikipedia.org/wiki/Liposome
    Another strategy for liposome drug delivery is to target endocytosis events. Liposomes can be made in a particular size range that makes them viable targets for natural macrophage phagocytosis. These liposomes may be digested while in the macrophage's phagosome, thus releasing its drug.

Peptide-targeted liposomal delivery of dexamethasone for ...

    https://www.researchgate.net/publication/332156264_Peptide-targeted_liposomal_delivery_of_dexamethasone_for_arthritis_therapy
    These results provide a proof-of concept for the use of a novel joint-homing peptide for targeted delivery of drugs including biologics or small molecule compounds to arthritic joints with ...

Receptor-targeted liposome-peptide-siRNA nanoparticles ...

    https://www.nature.com/articles/srep21881
    Feb 24, 2016 · In conclusion, this is the first study to develop and show that receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient and safe non …Author: Yu-Wai-Man C, Tagalakis Ad, Manunta, Hart Sl, Khaw Pt

Integrin Targeting and Toxicological Assessment of Peptide ...

    https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.12692
    Oct 21, 2016 · In addition, there was uptake of liposomes with peptide 2 in HUVECs in the co‐culture with activated macrophages. Liposomes with peptide 3 only showed uptake in the co‐culture, indicating that it was mainly engulfment by macrophages. These reflections stem from observations in cultured cells, which is the test system utilized in this study.Author: Ali Kermanizadeh, Klaus Villadsen, Ragnhild Garborg Østrem, Knud Jørgen Jensen, Peter Møller, Steffe...

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