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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338447/
Co-assembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro.Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein-mimetic peptide, localize at plaque sites in LDL receptor knockout mice with or ...Author: Miranda M. So, Neel A. Mansukhani, Erica B. Peters, Mazen S. Albaghdadi, Zheng Wang, Charles M. Rube...
https://www.sciencedirect.com/science/article/pii/S0169409X1630237X
The design of peptide-amphiphiles as functional ligands for liposomal anticancer drug and ... The AG86 was designed as a peptide-amphiphile and used as a ligand for targeting HeLa cervical cancer ... F. Wang, L. Chen, R. Zhang, Z. Chen, L. ZhuRGD peptide conjugated liposomal drug delivery system for enhance therapeutic efficacy in ...Author: Huihui Kuang, Sook Hee Ku, Efrosini Kokkoli
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/amphiphile
Peptide amphiphiles have been explored for drug and gene delivery for the treatment of brain tumors (Table 5.4). Yi et al. (2014) , using the amphiphilic R 3 V 6 peptide that self-assembles into micelles, studied the potential of this amphiphile for the delivery of VEGF siRNA and carmustine to C6 glioblastoma cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359574/
Jan 19, 2019 · A dual behavior is observed: on the one hand they can fulfill a structural and bioactive role. In this review, we focus on the design and the characterization of drug delivery systems using peptide-based carriers; moreover, we will also highlight the peptide ability to self-assemble and to actively address nanosystems toward specific targets.Author: Diego Tesauro, Antonella Accardo, Carlo Diaferia, Vittoria Milano, Jean Guillon, Luisa Ronga, Filome...
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(19)30186-5
Self-assembly of designed synthetic peptides is a versatile strategy to generate functional materials for many applications. Given the biological relevance of their amino acid composition, one logical application for this class of materials lies in drug and therapeutic delivery. Peptide design alters the ultimate device form factor, ranging from circulating nanostructures to locally applied ...Author: Matthew J. Sis, Matthew J. Webber
https://www.researchgate.net/publication/323125109_Peptide_Amphiphile_Nanostructures_for_Targeting_of_Atherosclerotic_Plaque_and_Drug_Delivery
Peptide amphiphile (PA) monomers that self-assemble into nanofibers were chosen as the delivery vehicle. ... Targeted drug delivery is a fast growing industry in healthcare and technologies are ...
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/adbi.201700123
Self‐assembled peptide amphiphile nanofibers incorporating an apolipoprotein A1‐mimetic peptide are designed as vehicles in a targeted drug‐delivery platform for atherosclerosis. These nanofibers enc...Author: Miranda M. So, Neel A. Mansukhani, Erica B. Peters, Mazen S. Albaghdadi, Zheng Wang, Charles M. Rube...
https://pubs.acs.org/doi/abs/10.1021/acsnano.5b06025
Noncompressible torso hemorrhage is a leading cause of mortality in civilian and battlefield trauma. We sought to develop an i.v.-injectable, tissue factor (TF)-targeted nanotherapy to stop hemorrhage. Tissue factor was chosen as a target because it is only exposed to the intravascular space upon vessel disruption. Peptide amphiphile (PA) monomers that self-assemble into nanofibers were chosen ...Author: Courtney E. Morgan, Amanda W. Dombrowski, Charles M. Rubert Pérez, Edward S.M. Bahnson, Nick D. Tsih...
https://pubs.acs.org/doi/full/10.1021/acsami.6b12647
A tumor targeting redox-responsive drug delivery system (DDS) with bioactive surface was constructed by immobilizing peptide-based amphiphile C12-CGRKKRRQRRRPPQRGDS (defined as ADDA-TCPP) onto the mesoporous silica nanoparticles (MSNs) as an end-capping nanovalve, which consists of two main segments: a hydrophobic alkyl chain ADDA and a hydrophilic amino acid sequence containing a …Author: Yin-Jia Cheng, Ai-Qing Zhang, Jing-Jing Hu, Feng He, Xuan Zeng, Xian-Zheng Zhang
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