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https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0365-y
Apr 13, 2018 · Since PEI-pSiNP delivery of siRNA is a biocompatible and versatile platform, it allowed us to characterise the MRP1 knockdown approach and to validate the decrease in proliferation of GBM in vivo. We demonstrated that the siRNA delivery resulted in MRP1 downregulation at …Author: Wing Yin Tong, Wing Yin Tong, Wing Yin Tong, Mohammed Alnakhli, Richa Bhardwaj, Sinoula Apostolou, S...
https://www.sciencedirect.com/science/article/pii/S0968089610003354
PEI/siRNA or pullulan-containing PEI/siRNA complexes were delivered into mice through the tail vein either by a hydrodynamics- or non-hydrodynamics-based injection. The incidence of mortality was found to increase with an increase in the nitrogen/phosphorus (N/P) ratio of PEI/siRNA complexes.Author: Jeong-Hun Kang, Yoichi Tachibana, Wakako Kamata, Atsushi Mahara, Mariko Harada-Shiba, Tetsuji Yamaok...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403700/
Aug 27, 2018 · To design a siRNA carrier with improved stability for systemic siRNA delivery, DA-PEI was further modified by introducing thiophenonyl groups (TP-DA-PEI). When complexed with siRNA having thiol groups at each end, the TP-DA-PEI conjugate formed a stable nano-sized polyplex.Author: Yin Y, Lee Je, Kim Nw, Lee Jh, Lim Sy, Kim Es, Park Jw, Lee Ms, Jeong Jh
https://www.sciencedirect.com/science/article/pii/S216225311730241X
The mechanism of PEI clearance is not yet completely clarified, but no cumulative toxicity has been observed in any in vivo study, and the 4 to 12 kDa PEI used here is among the lowest molecular weight PEIs that can be used for siRNA delivery. 53 The extensive in vivo experience and absence of immunogenicity of PEIs is advantageous to other shuttle systems, such as the large complexes with viral vectors or loading of siRNA …Author: Christin Helmschrodt, Sabrina Höbel, Sandra Schöniger, Anne Bauer, Jana Bonicelli, Marieke Gringmuth...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155750/
The DNA/siRNA co-delivery system has been considered a promising approach for cancer therapy to simultaneously express and inhibit tumor suppressor genes and overexpressed oncogenes, respectively, triggering synergistic anti-cancer effects. Polyethylenimine (PEI) has been identified as an efficient non-viral vector for transgene expression.Author: Shu-Fen Peng, Hung-Kun Hsu, Chun-Cheng Lin, Ya-Ming Cheng, Kuang-Hsing Hsu
https://onlinelibrary.wiley.com/doi/10.1002/smll.201001522
Jan 18, 2011 · A higher knockdown efficiency of siRNA delivered by PEI‐GO than by PEI is achieved. Sequential delivery of siRNA and DOX by the PEI‐GO nanocarrier shows a synergistic effect, which leads to significantly improved chemotherapy efficacy.Author: Liming Zhang, Zhuoxuan Lu, Qinghuan Zhao, Jie Huang, He Shen, Zhijun Zhang
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