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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314506/
Feb 02, 2015 · We found that the 1/1/4 D/S/P polyplex is a better composition for co-delivery of DNA and siRNA as it resulted in higher DNA and siRNA transfection with reduced toxicity than other polyplex compositions tested. Co-delivery of siRNA and pDNA using PEI-based carrier is a promising approach to maximize gene transfection efficiency.Author: Shan Lu, Shan Lu, Viola B. Morris, Vinod Labhasetwar
https://www.sciencedirect.com/science/article/pii/S0928493117331077
PLGA based delivery system with stearic acid (StA) molecules attached to PEI backbone (PEI-StA) could protect siRNA complexes against degradation in serum . This strategy could lead targeted siRNA delivery to dendritic cells (DCs).Author: Zejun Xu, Danyang Wang, Yanqin Cheng, Mingshi Yang, Mingshi Yang, Lin-Ping Wu
https://www.sciencedirect.com/science/article/pii/S0968089610003354
siRNA-based therapeutics are recognized as a useful approach for liver (hepatic) diseases such as hepatitis B and C, but development of liver-targeted siRNA delivery system is an important problem to solve. 1 In the present study, pullulan, a water-soluble polysaccharide, was introduced into PEI to increase liver-targeting efficiency.Author: Jeong-Hun Kang, Yoichi Tachibana, Wakako Kamata, Atsushi Mahara, Mariko Harada-Shiba, Tetsuji Yamaok...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171788/
Jul 03, 2018 · 5.2. A developed novel multifunctional delivery system based on PEI for co-delivery. Recently, several delivery systems based on PEI development for cancer treatment have been introduced . Nanocarriers have an important role in delivery of drug-gene combinations to cancer cells .Author: Abbas Zakeri, Mohammad Amin Jadidi Kouhbanani, Nasrin Beheshtkhoo, Vahid Beigi, Seyyed Mojtaba Mousa...
https://link.springer.com/article/10.1007%2Fs13346-016-0306-y
Jun 22, 2016 · The non-viral delivery of small RNA molecules like siRNAs still poses a major bottleneck for their successful application in vivo. This is particularly true with regard to crossing physiological barriers upon systemic administration. We have previously established polyethylenimine (PEI)-based complexes for therapeutic RNA formulation. These nanoplexes mediate full RNA protection against ...Author: Alexander Ewe, Sabrina Höbel, Claudia Heine, Lea Merz, Sonja Kallendrusch, Ingo Bechmann, Felicitas ...
https://www.sigmaaldrich.com/technical-documents/articles/material-matters/functionalized-pei-and-its-role-in-gene-therapy.html
A multifunctional, cationic triblock copolymer based on PEG, poly(ε-caprolactone) (PCL), and PEI was designed for the delivery of siRNA. 10 The hydrophobic PCL domain increased the affinity for the cell membrane, maintaining better internalization. Since this layer can also serve as a reservoir for hydrophobic substances, the system has the ...
https://www.hindawi.com/journals/bmri/2013/782041/
Currently, there are six cancer clinical trials underway using nanoparticle-based siRNA delivery, all in Phase I, evaluating the initial safety and utility of these treatments (Table 1). All the nanoparticle-formulated siRNA delivery systems for cancer therapy that are currently in clinical trials are based on polymers or liposomes.Author: Jong-Min Lee, Tae-Jong Yoon, Young-Seok Cho
https://iopscience.iop.org/article/10.1088/1361-6528/ab313d
Jul 29, 2019 · The delivery of siRNA using polymeric-based nanoparticles (e.g. PEI) can exhibit severe toxicity towards different cell lines. It was found that the increasing the number of cationic groups or the concentration of the delivery system increased the toxicity level. ... Essex S et al 2015 Phospholipid-modified PEI-based nanocarriers for in vivo ...Author: Waleed M. Hussein, Waleed M. Hussein, Yee S. Cheong, Chang Liu, Genan Liu, Anjuman Ara Begum, Maria ...
https://www.researchgate.net/publication/336161535_Rekindling_RNAi_Therapy_Materials_Design_Requirements_for_In_Vivo_siRNA_Delivery
factor in PEI-based nanoparticles for siRNA delivery is the N/P . ratio, which is the molar ratio between the nitrogen in the PEI . to the phosphorus in the siRNA. An N/P ratio greater than 10 .
https://www.polyplus-transfection.com/products/in-vivo-jetpei/
in vivo-jetPEI ® is perfectly suited to study gene function in vivo and provides the easiest method for the validation of in vitro functional studies into animals. Read more… Cancer Therapy. in vivo-jetPEI ®-based nucleic acid delivery is now widely used for tumor growthApplications: in vivo functional studies, Cancer therapy, Vaccination/immunization, Genome editing
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