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https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201901489
Extending our approach to liposome‐mediated, intracellular drug delivery, we first measured the in vitro cytotoxicity (MDA‐MB 231 cells, WST assay) of doxorubicin‐filled E PEG ‐ and F PEG ‐liposomes (4 mol% PEG 5000), before and after light activation, and compared this …Author: Li Kong, Quanchi Chen, Frederick Campbell, Ewa Snaar‐Jagalska, Alexander Kros
https://medschool.ucsd.edu/research/GRTC/Documents/Heparosan-coated%20liposomes%20for%20drug%20delivery%20%20Glycobiology%20%20Oxford%20Academic.pdf
Liposomal encapsulation is a useful drug delivery strategy for small molecules, especially che-motherapeutic agents such as doxorubicin. Doxil® is a doxorubicin-containing liposome (“dox-liposome”) that passively targets drug to tumors while reducing side effects caused by free drug permeating and poisoning healthy tissues.
https://pubs.acs.org/doi/10.1021/acs.chemrev.5b00046
Liposomal doxorubicin loaded PLGA-PEG-PLGA based thermogel for sustained local drug delivery for the treatment of breast cancer. Artificial Cells, Nanomedicine, and Biotechnology 2019 , 47 (1) , 181-191.Author: Bhushan S. Pattni, Vladimir V. Chupin, Vladimir P. Torchilin
https://www.jenkemusa.com/applications-pegs-drug-delivery-targeted-diagnostics
R&D efforts on novel applications for PEG derivatives, published in the first half of 2014, are focused in majority on drug delivery and targeted diagnostics, either via direct PEGylation of therapeutics [ 2, 3, 21, 62 – 65 ]; or via PEG-containing vehicles, such as nanoparticles [ 64,...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposomal-drug-delivery
Among many drug delivery systems, liposomal drug delivery is the most extensively investigated in the treatment of topical disorders such as psoriasis, skin cancer, and atopic dermatitis. This delivery approach provides enhanced efficacy and lowered the incidence of side effects as compared with conventional formulations, whereas it also reduces skin irritation, staining, and attribute-controlled …
https://www.sciencedirect.com/science/article/pii/B9780081017500000015
Doxil (the drug doxorubicin loaded into a PEGylated liposome) became the first FDA-approved drug delivery system in clinical use . Doxil “stealth” liposomes increase the bioavailability of doxorubicin nearly 90-fold after 1 week, in comparison to free doxorubicin, which has a drug half-life of 72 hours and a circulation half-life of 36 ...Author: Zhiqiang Shen, Alessandro Fisher, Wing K. Liu, Ying Li
https://www.tandfonline.com/doi/abs/10.1080/10717544.2016.1177136?needAccess=true
Liposomes were the first nanoscale drug to be approved for clinical use in 1995. Since then, the technology has grown considerably, and pioneering recent work in liposome-based delivery …Author: Claudia Zylberberg, Sandro Matosevic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664963/
Dec 01, 2015 · Biological challenges facing liposomal drug delivery systems. As with any foreign particle that enters the body, liposomes encounter multiple defense systems aimed at recognition, neutralization, and elimination of invading substances. These defenses include the RES, opsonization, and immunogenicity (Willis and Forssen, 1998).Author: Lisa Sercombe, Tejaswi Veerati, Tejaswi Veerati, Fatemeh Moheimani, Sherry Y. Wu, Anil K. Sood, Susa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426795/
Current research on PEG liposomes has concentrated on attaching PEG to the liposome surface in a removable fashion, in order to facilitate subsequent liposome capture by the cells. After PEG liposomes accumulate at the target site through the EPR effect, the PEG coating is detached under the action of local pathological conditions (decreased pH in tumors).Author: Maria Laura Immordino, Franco Dosio, Luigi Cattel
https://www.omicsonline.org/open-access/liposomes-for-drug-delivery-2155-952X276-97370.html
Liposomes are a novel drug delivery system (NDDS), they are vesicular structures consisting of bilalyers which form spontaneously when phospholipids are dispersed in water. They are microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of lipid bilayers.Author: Durgavati Yadav, Kumar Sandeep, Deepak Pandey, Ranu Kumari Dutta
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