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https://www.sciencedirect.com/science/article/pii/S093964111000113X
This investigation verifies the formation of polyelectrolyte complexes between chitosan and pectin at pH values in the vicinity of the pKa interval of the two polymers and confirms the potential of these complexes, capable of achieving antipsychotic drug delivery in the nasal cavity.Author: Barbara Luppi, Federica Bigucci, Angela Abruzzo, Giuseppe Corace, Teresa Cerchiara, Vittorio Zecchi
https://www.researchgate.net/publication/227047692_Pectin_in_controlled_drug_delivery_-_A_review
The intranasal and vaginal routes of drug delivery using pectin are considered as an alternative to injection methods; since the mucosa in both cases has a high degree of vascularization, there is ...
https://link.springer.com/article/10.1007/s10570-006-9095-7
Nov 10, 2006 · Pectin derivatives carrying primary amine groups were more mucoadhesive and have shown potential in nasal drug delivery and other mucosal drug delivery. Pectin derivatives with highly esterified galacturonic acid residues are more hydrophobic and able to sustain the release of incorporated fragrances for a prolonged duration.Author: LinShu Liu, Marshall L. Fishman, Kevin B. Hicks
https://www.sciencedirect.com/science/article/pii/S0168365912000296
PecSys TM is a pectin based nasal drug delivery system in development by Archimedes Pharma Ltd. Pectins are heterogenous polysaccharides comprising a backbone of galacturonic acids units linked by α-1,4 bonds, with a component of neutral sugars such as galactose, xylose, rhamnose and arabinose either in the backbone or as side chains .Author: Lisbeth Illum
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649785/
Nasal cavity has been used from ancient time as a drug delivery route to alleviate diseases and disorders. One of the ‘panchakarmas’ stated in Ayurveda is ‘nasyakarma’, a practice in which a drug is administered through the nostrils[].Nasal cavity is an excellent doorway for the entry of the drug moiety to systemic circulation and central nervous system.
https://www.researchgate.net/publication/50420661_Polysaccharide_drug_delivery_systems_based_on_pectin_and_chitosan
Polysaccharide drug delivery systems based on pectin and chitosan. ... Major sites for pectin drug delivery systems ... Nasal drug delivery is limited by the small sample volume that can be deli vered
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017442/
Apr 18, 2018 · Besides its importance in the food industry, pectin has potential uses in many other fields, like medicine, as a carrier for controlled drugs or bioactive release [8,14], for instance, in nasal, ocular and oral drug delivery [15,16,17] and wound healing .Author: Claudia Lara-Espinoza, Elizabeth Carvajal-Millán, René Balandrán-Quintana, Yolanda López-Franco, Agu...
https://www.tandfonline.com/doi/abs/10.1517/17425240902939135
Mar 06, 2015 · PecSys™ (PS) is a proprietary pectin-based drug delivery system designed to gel when applied to mucosal surfaces and with potential areas of application for drugs used in local and systemic disease therapy. The current area of focus is intranasal drug delivery where PS is being used to optimise absorption of lipophilic drugs into the systemic circulation.Author: Peter Watts, Alan Smith
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