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https://www.sciencedirect.com/science/article/pii/S0142961203002138
Therefore, as we can see in the following examples, the use of calcium pectinate matrices for colon-specific drug delivery seems highly restricted to low water soluble drugs. In one experiment, tablets consisting of calcium pectinate and insulin, a water soluble protein drug, showed no ability to delay the release of incorporated insulin [37] .Author: LinShu Liu, Marshall L. Fishman, Joseph Kost, Kevin B. Hicks
https://www.sigmaaldrich.com/catalog/papers/12763460
Pectin-derived matrices are now being examined and tested for controlled drug delivery. Pectin is intact in the upper gastrointestinal tract and degraded by colonic microflora. The composition of this microflora remains relatively consistent across a diverse human population.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066368/
pectin-based colon-specific oral drug delivery system and colon cancer Over the past 5 years, in vivo assessments indicate that colon-specific pectin-based oral dosage forms can be designed primarily through coating of drug matrix with pectin-ethylcellulose or Eudragit film ( 85 , 91 ).Author: Tin Wui Wong, Gaia Colombo, Fabio Sonvico
https://www.researchgate.net/publication/10747071_Pectin-based_systems_for_colon-specic_drug_delivery_via_oral_route
Pectin-based systems for colon-speci?c drug delivery via oral route Article · Literature Review in Biomaterials 24(19):3333-43 · September 2003 with 1,280 Reads How we measure 'reads'
https://www.academia.edu/15008421/Pectin-based_systems_for_colon-specific_drug_delivery_via_oral_route
Pectin-based systems for colon-specific drug delivery via oral route
https://link.springer.com/article/10.1007%2FBF02942291
Jun 01, 2004 · Abstract. Drug delivery systems that are based on pectin have been studied for colon specific delivery using the specific activity of colon microflora. The aim of this study was to design a novel method of manufacturing pectin microspheres without oils and surfactants and to investigate the potential use of the pectin microsphere as an oral...Author: Chang-Moon Lee, Dong-Woon Kim, Hyun-Chul Lee, Ki-Young Lee
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