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https://www.researchgate.net/publication/24399833_PecSys_In_situ_gelling_system_for_optimised_nasal_drug_delivery
PecSys: In situ gelling system for optimised nasal drug delivery Article · Literature Review in Expert Opinion on Drug Delivery 6(5):543-52 · June 2009 with 238 Reads How we measure 'reads'
https://www.tandfonline.com/doi/abs/10.1517/17425240902939135
Mar 06, 2015 · PecSys™ (PS) is a proprietary pectin-based drug delivery system designed to gel when applied to mucosal surfaces and with potential areas of application for drugs used in local and systemic disease therapy. The current area of focus is intranasal drug delivery where PS is being used to optimise absorption of lipophilic drugs into the systemic circulation.Author: Peter Watts, Alan Smith
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865781/
In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the body, but once administered, undergo gelation in situ, to form a gel.The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649785/
Another famous example of ion responsive in situ gelling nasal drug delivery is PecFent ® (fentanyl citrate) nasal spray which uses Archimedes Pharma's patented drug delivery system, PecSys™. PecSys™ is a proprietary pectin-based drug delivery system which delivers fentanyl in controlled manner with fast onset of action and is designed as ...
https://www.ijpsonline.com/articles/smart-polymers-in-nasal-drug-delivery.pdf
Nasal drug delivery has now been recognized as a promising route for drug delivery due to its capability of transporting a drug to systemic circulation and central nervous system. Though nasal mucosa offers improved bioavailability and ... [13]nasal cavity . Therefore in situ nasal gelling systems with smart polymers (Stimuli responsive ...Author: Ankita Chonkar, Usha Nayak, N Udupa
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619451/
Jul 17, 2012 · Keywords: Nasal drug delivery, pectin, formulation, no-drip, gels, in situ gelling, inclined plate, anatomical nasal cast, in vitro models, mucosal drug delivery Introduction The nasal route is an increasingly important mode of drug delivery, with a growing number of products available for systemic action alongside long established locally ...
https://www.sciencedirect.com/science/article/pii/S181808761730990X
Among these, the ophthalmic in-situ gel has attained a great attention over the past few years. This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system.Author: Yumei Wu, Yuanyuan Liu, Xinyue Li, Dereje Kebebe, Dereje Kebebe, Bing Zhang, Jing Ren, Jun Lu, Jiawe...
https://www.ijpsonline.com/articles/smart-polymers-in-nasal-drug-delivery.html
Another famous example of ion responsive in situ gelling nasal drug delivery is PecFent® (fentanyl citrate) nasal spray which uses Archimedes Pharma’s patented drug delivery system, PecSys™. PecSys™ is a proprietary pectin-based drug delivery system which delivers fentanyl in controlled manner with fast onset of action and is designed as ...
https://www.slideshare.net/shreeraj9183/insitu-gel-drug-delivery-system
Aug 28, 2012 · In situ forming Nasal drug delivery systems Gellan gum and xanthan gum were used as in situ gel forming polymers Animal studies were conducted using an allergic rhinitis model and the effect of in situ gel on antigen induced nasal symptoms in sensitized rats was observed In-situ gel was found to inhibit the increase in nasal symptoms as ...
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