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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884307/
Apr 19, 2002 · Part I of this review on pulmonary drug delivery addresses the physiological factors affecting therapeutic effectiveness of inhaled drug therapy, including aerosol particle size, airway geometry, lung clearance mechanisms, and lung disease.Author: N. R. Labiris, M. B. Dolovich
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733285/
May 30, 2019 · Mouth-throat deposition and lung delivery simulation input and results. (a) Emitted aerodynamic particle size distribution of detached particles from the device (determined by NGI measurements), (b) losses in the mouth-throat region (determined by biophysical simulation) and (c) aerodynamic particle size distribution delivered into the lungs (determined by biophysical simulation), …Author: Myrna B. Dolovich, Andreas Kuttler, Thomas J. Dimke, Omar S. Usmani
https://www.atsjournals.org/doi/full/10.1513/pats.200409-046TA
Dec 01, 2004 · Particle behavior in the human respiratory tract is well understood and can be used to (1) estimate particle deposition in all regions of the respiratory tract for any aerosol respired at any pattern, and (2) optimize targeting of all regions of the respiratory tract in respiratory drug delivery.Extrathoracic and alveolar regions can effectively be targeted with mono- and polydisperse aerosols ...Author: Joachim Heyder
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Pulmonary drug delivery is getting more and more magnitude. This is on account of the specific physiological environment of the lung as an absorption and treatment organ. The development of inhalable insulin can be perceived as a milestone in pulmonary drug delivery.
http://www.pharmtech.com/pulmonary-drug-delivery-particle-engineering-inhaled-therapeutics
Feb 02, 2014 · The delivery of the drug product to the lung is mainly controlled by the incoming particle size of the drug substance; however, other factors such as the propellant, excipients, amount metered from the valve, and actuator orifice size play added roles in the overall final particle size distribution.
https://www.sciencedirect.com/science/article/pii/S0091674909014717
Particle size and delivery device differences of inhaled corticosteroids. Asthma is known to be a disease of the entire respiratory tract, including the large, intermediate, and small airways.Author: Chet Leach, Gene L. Colice, Allan Luskin
https://www.pharmamanufacturing.com/assets/Media/MediaManager/Microfluidics_achieve-optimal-part-size_inhalation-therapy.pdf
Achieving Optimal Particle Size Distribution in Inhalation Therapy . By Bob Bruno . Inhalation therapy has proven to be an effective method of administering a number of pharmaceuticals for more than a century. However, achieving the optimal particle size for a treatment with particular pharmaceutical formulations has been a troublesome task.File Size: 123KB
https://www.atsjournals.org/doi/full/10.1164/rccm.200410-1414OC
Dec 15, 2005 · Rationale: Aerosol particle size influences the extent, distribution, and site of inhaled drug deposition within the airways. Objectives: We hypothesized that targeting albuterol to regional airways by altering aerosol particle size could optimize inhaled bronchodilator delivery. Methods: In a randomized, double-blind, placebo-controlled study, 12 subjects with asthma (FEV 1, 76.8 ± 11.4% ...Author: Omar S. Usmani, Martyn F. Biddiscombe, Peter J. Barnes
https://journal.chestnet.org/article/S0012-3692(16)34835-8/fulltext
We studied the relation between lung dose and particle size for HFA-BDP and CFC-BDP delivered by pMDIs with a spacer device at different V t s in an anatomically correct upper airway model of an infant. The lung dose of HFA-BDP was 3.5-fold to almost 15-fold higher compared with CFC-BDP for …Author: Hettie M. Janssens, Johan C. de Jongste, Wim C.J. Hop, Harm A.W.M. Tiddens
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