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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636209/
In their 1998 paper, Suman and colleagues reported that drug delivery by nasal nebulizers could enhance particle deposition in the pharynx and lungs compared to aqueous sprays, and their 1999 paper suggested that lung deposition is the result of particle size within the range 2–10µm.Author: Dennis O. Frank, Julia S. Kimbell, Sachin Pawar, John S. Rhee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review. Per Gisle Djupesland . Author ... In the context of nasal drug delivery, ... the drug is atomized when delivered from a jet outlet. The dose and particle size vary with the force applied, and when the pressure is released, nasal secretion and ...Author: Per Gisle Djupesland
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://pdfs.semanticscholar.org/b394/fa2b5d6abd97f8651d1abf0f48009ce82042.pdf
ing an aerodynamic particle size. This can then be directly related to the behaviour of particles within the nasal passages and can be used to predict the aerosol deposition site during drug delivery and the likely drug bioavailability. CI or MSLI measurements can be time-consuming and therefore Particle size characterisation in nasal sprays ...
https://quizlet.com/375860677/nasal-drug-delivery-flash-cards/
Increase air flow velocity & particle size = will increase chance of deposition Want to avoid impaction in respiratory delivery (not nasal delivery) 5 to 10 micron particle size range = likely to end up in the lungs Anything over 10 microns = will end up in nasal cavity Nasal spray = coarse spray
https://www.researchgate.net/publication/290530969_Particle_size_determination_of_nasal_drug_delivery_system_A_review
The generated nasal spray was also characterized in terms of the spray pattern, deposition within a human nose model and droplet size, where droplets considered fine for nasal drug delivery (1) (2 ...
http://www.nasoneb.com/pdfs/NasoNebparticlesizeairflow.pdf
When pulmonary devices are adapted for nasal delivery using nasal adapters, the particle size generated remains in the 3-5 micron range. In this size range, studies have demonstrated that 3% of the drug deposits in the nasal cavity, 18-22% deposits in the lungs, and the rest is lost to inhalation8.
https://www.atsjournals.org/doi/full/10.1513/pats.200409-046TA
Dec 01, 2004 · Particle behavior in the human respiratory tract is well understood and can be used to (1) estimate particle deposition in all regions of the respiratory tract for any aerosol respired at any pattern, and (2) optimize targeting of all regions of the respiratory tract in respiratory drug delivery.Extrathoracic and alveolar regions can effectively be targeted with mono- and polydisperse aerosols ...Author: Joachim Heyder
https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
become the dominant delivery principle in nasal drug delivery. Direct-Haler is the first drug deliv-ery company to take advantage of this device-dependent reflex for enhancing nasal drug deliv-ery. Naturally, the increased interest in this princi-ple for enhanced nasal delivery has recently led other companies to seek exploitation of the same
https://www.slideshare.net/kawii/nasal-drug-delivery-system-41893460
Nov 22, 2014 · INTRODUCTION Administration of drug through nasal route is referred as Nasal drug delivery system. Nasal route is an alternative to invasive administrations and provides a direct access to the systemic circulation. Intranasal Medication administration offers a …
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